Greater Visceral Fat but No Difference in Measures of Total Body Fat in Ambulatory Children With Spastic Cerebral Palsy Compared to Typically Developing Children.
Greater Visceral Fat but No Difference in Measures of Total Body Fat in Ambulatory Children With Spastic Cerebral Palsy Compared to Typically Developing Children.
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DOI：
10.1016/j.jocd.2018.09.006
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Modlesky CM
中科院分区：
文献类型：
--
作者：
Whitney DG;Singh H;Zhang C;Miller F;Modlesky CM
脑性瘫痪（CP）患者患肥胖症和肥胖相关并发症的风险增加。对CP患者全身脂肪的研究不一致，对CP儿童腹部脂肪的研究缺乏。本研究的目的是确定与正常发育的儿童相比，患有痉挛性CP的非卧床儿童是否有更大的中心性肥胖。18名患有痉挛性CP的非卧床儿童（n = 5名女孩; 8.6 ± 2.9岁）和18名年龄、性别和种族匹配的典型发育儿童（对照组; 8.9 ± 2.1岁）参加了这项横断面研究。使用粗大运动功能分类系统将CP儿童分类为I或II。双能X线吸收测定法评估身体组成，包括全身、躯干和腹部脂肪量、去脂肪量、脂肪量指数（FMI）和去脂肪量指数（FFMI）。全身的脂肪量、去脂肪量、FMI和FFMI，躯干的脂肪量、去脂肪量和FFMI，或腹部的脂肪量、内脏脂肪量和皮下脂肪量均无组间差异（p> 0.05）。与对照组相比，CP儿童的躯干FMI、腹部FMI和内脏FMI较高（p <0.05）。尽管不显著（p = 0.088），但CP儿童的皮下FMI较高。痉挛型脑瘫的非卧床儿童有中心性肥胖，特别是在内脏区域，尽管全身脂肪的测量没有差异。这与CP患者心脏代谢疾病进展的关系需要进一步研究。
Individuals with cerebral palsy (CP) are at increased risk for obesity and obesity-related complications. Studies of total body fat in those with CP are inconsistent and studies of abdominal fat are lacking in children with CP. The objective of this study was to determine if ambulatory children with spastic CP have greater central adiposity compared to typically developing children. Eighteen ambulatory children with spastic CP (n=5 girls; 8.6 ± 2.9 years) and 18 age-, sex- and race-matched typically developing children (controls; 8.9 ± 2.1 years) participated in this cross-sectional study. Children with CP were classified as I or II using the Gross Motor Function Classification System. Dual-energy x-ray absorptiometry assessed body composition, including total body, trunk and abdominal fat mass, fat-free mass, fat mass index (FMI) and fat-free mass index (FFMI). There were no group differences in fat mass, fat-free mass, FMI, and FFMI in the total body, fat mass, fat-free mass and FFMI in the trunk, or fat mass, visceral fat mass and subcutaneous fat mass in the abdomen (p > 0.05). Compared to controls, children with CP had higher trunk FMI, abdominal FMI and visceral FMI (p < 0.05). Although marginally insignificant (p = 0.088), children with CP had higher subcutaneous FMI. Ambulatory children with spastic CP have elevated central adiposity, especially in the visceral region, despite no differences in measures of total body fat. How this relates to cardiometabolic disease progression in those with CP requires further investigation.
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影响因子：
5.1
作者：
Johnson, David L.;Miller, Freeman;Modlesky, Christopher M.
通讯作者：
Modlesky, Christopher M.
影响因子：
5.9
作者：
Cremer, Nicole;Hurvitz, Edward A.;Peterson, Mark D.
通讯作者：
Peterson, Mark D.
DOI：
10.1111/j.1469-8749.2007.00647.x
发表时间：
2007-09-01
影响因子：
3.8
作者：
Day, Steven M.;Wu, Yvonne W.;Reynolds, Robert J.
通讯作者：
Reynolds, Robert J.
影响因子：
3.8
作者：
Duran, Ibrahim;Schulze, Josefa;Schoenau, Eckhard
通讯作者：
Schoenau, Eckhard
影响因子：
5.3
作者：
Rogozinski, Benjamin M.;Davids, Jon R.;Blackhurst, Dawn W.
通讯作者：
Blackhurst, Dawn W.