Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS.
Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS.
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DOI：
10.1002/mrm.24775
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发表时间：
2014-03
影响因子：
3.3
通讯作者：
Krug, Roland
中科院分区：
文献类型：
--
作者：
Karampinos, Dimitrios C.;Melkus, Gerd;Baum, Thomas;Bauer, Jan S.;Rummeny, Ernst J.;Krug, Roland
关键词：
本研究的目的是测试基于化学位移的水脂肪成像在存在小梁骨的情况下测量骨髓脂肪分数的相对性能，以单体素磁共振波谱（MRS）作为参考标准。对七名健康志愿者的股骨近端进行六回波梯度回波成像和单体素 MRS 测量。根据可测量的脂肪峰的大小和甘油三酯化学结构的先验知识来表征骨髓脂肪谱，以便从 MRS 中重叠的宽脂肪峰中准确提取水峰。然后将基于成像的脂肪分数结果与基于 MRS 的结果进行比较，无论是否考虑 MRS 中存在短 T2* 水成分。使用 MRS 模型，未考虑基于成像的水分数的短 T2* 物种，明显低估了脂肪分数。使用考虑短 T2* 物种的 MRS 模型的脂肪分数与基于成像的脂肪分数之间观察到良好的等效性 (R2=0.87)。在比较基于 MRS 和基于成像的脂肪分数结果时，必须考虑短 T2* 水物种对骨髓脂肪定量的影响。
The purpose of the present study was to test the relative performance of chemical shift-based water-fat imaging in measuring bone marrow fat fraction in the presence of trabecular bone, having as reference standard the single-voxel magnetic resonance spectroscopy (MRS). Six-echo gradient echo imaging and single-voxel MRS measurements were performed on the proximal femur of seven healthy volunteers. The bone marrow fat spectrum was characterized based on the magnitude of measurable fat peaks and an a priori knowledge of the chemical structure of triglycerides, in order to accurately extract the water peak from the overlapping broad fat peaks in MRS. The imaging-based fat fraction results were then compared to the MRS-based results both without and with taking into consideration the presence of short T2* water components in MRS. There was a significant underestimation of the fat fraction using the MRS model not accounting for short T2* species with respect to the imaging-based water fraction. A good equivalency was observed between the fat fraction using the MRS model accounting for short T2* species and the imaging-based fat fraction (R2=0.87). The consideration of the short T2* water species effect on bone marrow fat quantification is essential when comparing MRS-based and imaging-based fat fraction results.
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