Chemical shift-based water/fat separation in the presence of susceptibility-induced fat resonance shift.
Chemical shift-based water/fat separation in the presence of susceptibility-induced fat resonance shift.
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DOI：
10.1002/mrm.24157
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发表时间：
2012-11
影响因子：
3.3
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Karampinos, Dimitrios C.;Yu, Huanzhou;Shimakawa, Ann;Link, Thomas M.;Majumdar, Sharmila
关键词：
随着临床对不同器官脂肪定量的需求日益增长，基于化学位移的水/脂分离方法应运而生。准确地量化质子密度脂肪分数需要评估许多混杂因素，包括需要对脂肪光谱中存在的多个峰进行建模。最新的基于化学位移的定量水/脂肪分离方法依赖于具有预校准峰位置和预校准或自校准峰相对幅度的多峰脂肪光谱。然而，水/脂肪敏感性的差异会导致脂肪光谱共振位移，这取决于脂肪包裹体的形状和方向。由于细胞外脂的各向异性排列，这种效应在骨骼肌中特别有趣。在目前的工作中，磁化率诱导的脂肪共振位移对脂肪组分的影响被表征在传统的基于络合物的基于化学位移的水/脂肪分离方法中，该方法没有对磁化率诱导的脂肪共振位移进行建模。然后提出了一种新的算法，用于量化基于复数化学位移的水/脂分离方法中的共振位移，该方法考虑了信号模型中的脂肪共振位移，旨在提取关于脂类取向/几何信息。这项技术在体模上得到了验证，并在健康和糖尿病受试者的小腿肌肉系统中显示了初步的体内结果。
Chemical shift-based water/fat separation methods have been emerging due to the growing clinical need for fat quantification in different body organs. Accurate quantification of proton-density fat fraction requires the assessment of many confounding factors, including the need of modeling the presence of multiple peaks in the fat spectrum. Most recent quantitative chemical shift-based water/fat separation approaches rely on a multi-peak fat spectrum with pre-calibrated peak locations and pre-calibrated or self-calibrated peak relative amplitudes. However, water/fat susceptibility differences can induce fat spectrum resonance shifts depending on the shape and orientation of the fatty inclusions. The effect is of particular interest in the skeletal muscle due to the anisotropic arrangement of extracellular lipids. In the present work, the effect of susceptibility-induced fat resonance shift on the fat fraction is characterized in a conventional complex-based chemical shift-based water/fat separation approach that does not model the susceptibility-induced fat resonance shift. A novel algorithm is then proposed in order to quantify the resonance shift in a complex-based chemical shift-based water/fat separation approach that considers the fat resonance shift in the signal model, aiming to extract information about the orientation/geometry of lipids. The technique is validated in a phantom and preliminary in vivo results are shown in the calf musculature of healthy and diabetic subjects.
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影响因子：
3.3
作者：
Hernando, Diego;Liang, Zhi-Pei;Kellman, Peter
通讯作者：
Kellman, Peter
影响因子：
3.3
作者：
Hernando, D.;Hines, C. D. G.;Yu, H.;Reeder, S. B.
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Reeder, S. B.
影响因子：
3.3
作者：
Sprinkhuizen, Sara M.;Bakker, Chris J. G.;Bartels, Lambertus W.
通讯作者：
Bartels, Lambertus W.
影响因子：
3.3
作者：
SCHICK, F;EISMANN, B;LUTZ, O
通讯作者：
LUTZ, O
影响因子：
3.3
作者：
Hernando, D.;Haldar, J. P.;Liang, Z. -P.
通讯作者：
Liang, Z. -P.