Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects.
Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects.
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DOI：
10.1111/j.1365-2559.2007.02851.x
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发表时间：
2007-11
期刊：
影响因子：
6.4
通讯作者：
Chow AW
中科院分区：
文献类型：
--
作者：
Wilder-Smith EP;Ong WY;Guo Y;Chow AW
瞬时受体电位香草酸1（TRPV 1）在介导疼痛和热中起重要作用。在疼痛性神经病变中，表皮内TRPV 1神经纤维表达较低或不存在，表明产生的疼痛与感觉神经纤维不直接相关。最近的证据表明，角质形成细胞可能通过TRPV 1作为热受体。目的是研究与疼痛相关的神经病理性疾病患者表皮TRPV 1的表达。在一项远端小神经纤维神经病变（DISN; n = 13）和糖尿病神经病变（DN; n = 12）的前瞻性研究中，与对照组（n = 9）相比，使用泛轴突标记物PGP 9.5和表皮TPVR 1免疫反应性评估表皮内神经纤维密度。所有组的表皮内神经纤维均未显示TRPV 1免疫反应性。表皮角质形成细胞TRPV 1的中、强反应性在DISN组分别为41.8%和6%，DN组分别为32.9%和2.9%，对照组分别为25.4%和5.1%。与对照组相比，DISN中的中度角质形成细胞TRPV 1表达显著增加（P = 0.01）。我们的研究表明，在人类疼痛性神经病变，表皮TRPV 1的表达主要是在角质形成细胞。
The transient receptor potential vanilloid 1 (TRPV1) plays an important role in mediating pain and heat. In painful neuropathies, intraepidermal TRPV1 nerve fibre expression is low or absent, suggesting that pain generated is not directly related to sensory nerve fibres. Recent evidence suggests that keratinocytes may act as thermal receptors via TRPV1. The aim was to investigate epidermal TRPV1 expression in patients with neuropathic conditions associated with pain. In a prospective study of distal small nerve fibre neuropathy (DISN; n = 13) and diabetic neuropathy (DN; n = 12) intraepidermal nerve fibre density was assessed using the pan axonal marker PGP 9.5 and epidermal TPVR1 immunoreactivity compared with controls (n = 9). Intraepidermal nerve fibres failed to show TRPV1 immunoreactivity across all groups. There was moderate and strong TRPV1 reactivity of epidermal keratinocytes in 41.8% and 6% for DISN, 32.9% and 2.9% for DN and 25.4% and 5.1% for controls, respectively. Moderate keratinocyte TRPV1 expression was significantly increased in DISN compared with controls (P = 0.01). Our study suggests that in human painful neuropathies, epidermal TRPV1 expression is mainly in keratinocytes.
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DOI：
10.1186/1472-6874-5-2
发表时间：
2005-03-08
期刊：
BMC women's health
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1124/jpet.102.040675
发表时间：
2003-01-01
影响因子：
3.5
作者：
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影响因子：
14.5
作者：
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通讯作者：
Willison, HJ
影响因子：
2.5
作者：
Tsutsumi, S;Tomioka, A;Kohama, K
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影响因子：
3.6
作者：
Ständer, S;Moormann, C;Steinhoff, M
通讯作者：
Steinhoff, M