A recent perspective on alcohol, immunity, and host defense.

A recent perspective on alcohol, immunity, and host defense.
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DOI:
10.1111/j.1530-0277.2008.00842.x
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发表时间:
2009-02
期刊:
Alcoholism, clinical and experimental research
影响因子:
--
通讯作者:
Mandrekar P
Mandrekar P
中科院分区:
其他
文献类型:
--
作者:
Szabo G;Mandrekar P

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多线的临床和实验证据表明,无论是急性,中度和慢性,过量饮酒导致免疫系统功能的各种异常。炎症细胞和适应性免疫反应的改变反过来又导致酒精使用后感染和其他器官影响的发生率增加和结果不佳。这篇综述文章总结了最近的研究结果有关的免疫调节酒精及其后果对宿主防御微生物病原体和组织损伤。
Multiple line of clinical and experimental evidence demonstrates that both acute, moderate and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system. Altered inflammatory cell and adaptive immune responses in turn result in increased incidence and poor outcome of infections and other organ effects after alcohol use. This review article summarizes recent findings relevant to immunomodulation by alcohol and its consequences on host defense against microbial pathogens and tissue injury.
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