High RNA-Binding Motif Protein 3 (RBM3) Expression is Independently Associated with Prolonged Overall Survival in Intestinal-Type Gastric Cancer.
High RNA-Binding Motif Protein 3 (RBM3) Expression is Independently Associated with Prolonged Overall Survival in Intestinal-Type Gastric Cancer.
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DOI：
10.12659/msm.905314
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发表时间：
2017-12-21
期刊：
影响因子：
--
通讯作者：
Cai H
中科院分区：
文献类型：
--
作者：
Ye F;Jin P;Cai X;Cai P;Cai H
rna结合基序蛋白3 （RBM3）的高表达已被认为是多种癌症的有利临床病理因素，包括卵巢癌、结直肠癌、前列腺癌和乳腺癌。本研究的目的是探讨胃癌中RBM3表达的预后意义。免疫组化分析123例患者RBM3表达结果显示，与弥漫型（15例，8例）和混合型（30例，17例）相比，肠型（78例，59例）肿瘤中RBM3表达上调较多。RBM3在临床病理参数亚组间表达差异无统计学意义。RBM3的表达与p53密切相关，而与Ki-67不相关。Cox单因素分析显示，RBM3高表达与总生存时间延长密切相关（HR 0.504, 95% CI: 0.300-0.845， P=0.009）。多变量分析仍然支持这些关联，当调整年龄、性别、肿瘤大小、分化分级、TNM分期、淋巴浸润、Ki-67和p53表达（HR 0.541, 95% CI: 0.308-0.952， P=0.033），其中Lauren分级不包括在内。在所有因素调整后的模型中，劳伦评分是唯一具有独立预后意义的因素。这些结果得到了Kaplan-Meier分析的证实。因此，结合在肠型Lauren分级中观察到的RBM3表达上调，我们认为RBM3的上调是肠型Lauren分级患者总生存率较高的部分原因，这一点通过箱形图和Kaplan-Meier分析得到了证实。我们的研究结果表明，RBM3在胃癌中的高表达主要存在于Lauren级肠型，并且与较长的总生存时间相关。我们发现RBM3是一个潜在的预后良好的生物标志物，值得进一步验证。
High expression of the RNA-binding motif protein 3 (RBM3) has previously been described as a favorable clinicopathological factor in several cancers, including ovarian cancer, colorectal cancer, prostate cancer, and breast cancer. The aim of this study was to examine the prognostic implications of RBM3 expression in gastric cancer. Immunohistochemical analysis of RBM3 expression from 123 patients showed that upregulated RBM3 was mainly found in intestinal-type (n=78, case=59) cancer compared to diffuse-type (n=15, case=8) and mixed-type (n=30, case=17). There were no significant differences in RBM3 expression in subgroups of clinicopathological parameters. RBM3 expression was strongly associated with p53 but not with Ki-67. Cox univariate analysis revealed that high RBM3 expression was closely associated with prolonged overall survival time (HR 0.504, 95% CI: 0.300–0.845, P=0.009). Multivariate analysis remained supporting these associations when adjusted for age, sex, tumor size, differentiation grade, TNM stage, lymphatic invasion, and Ki-67 and p53 expression (HR 0.541, 95% CI: 0.308–0.952, P=0.033), where Lauren grade was not included. Lauren grade was the only factor with independent prognostic significance in a model adjusted for all factors. These results were confirmed by Kaplan-Meier analysis. Therefore, together with the upregulated RBM3 expression observed in intestinal-type of Lauren grade, we suggest that upregulation of RBM3 is partially responsible for the favorable overall survival in cases with intestinal Lauren grade, which is demonstrated by the box diagram and Kaplan-Meier analysis. Our results showed that high RBM3 expression in gastric cancer is mainly found in intestinal-type of Lauren grade and is associated with longer overall survival time. We found that RBM3 is a potential biomarker of good prognosis and deserves further validation.
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影响因子：
4.2
作者：
Kong Y;Zheng Y;Jia Y;Li P;Wang Y
通讯作者：
Wang Y
DOI：
10.1007/s101200100014
发表时间：
2001-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Seto, Y;Shimoyama, S;Yamamura, Y
通讯作者：
Yamamura, Y
影响因子：
2
作者：
Jang, Ho Hee;Lee, Hae Na;Lee, Won-Suk
通讯作者：
Lee, Won-Suk
DOI：
10.12659/msm.895333
发表时间：
2016-08-12
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Cui X;Huang Q;Li X;Liu F;Wang D;Yan D;Wang B;Yang C;Mi J;Tian G
通讯作者：
Tian G
影响因子：
2.6
作者：
Jonsson L;Gaber A;Ulmert D;Uhlén M;Bjartell A;Jirström K
通讯作者：
Jirström K