The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment.
The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment.
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DOI：
10.1186/1471-2334-10-227
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发表时间：
2010-07-29
影响因子：
3.7
通讯作者：
Webster JP
中科院分区：
文献类型：
--
作者：
Koukounari A;Donnelly CA;Sacko M;Keita AD;Landouré A;Dembelé R;Bosqué-Oliva E;Gabrielli AF;Gouvras A;Traoré M;Fenwick A;Webster JP
在发展中国家，无论是种间和/或属间和属内混合感染的任何组合，人体内的共感染和多寄生现象似乎都是普遍现象，而不是例外。混合感染可能产生协同或拮抗相互作用，从而在临床上影响个体和/或影响寄生虫流行病学。目前的研究通过超声评估了与曼氏血吸虫和血肿血吸虫相关的肝脏和膀胱发病率，并通过临床检查评估了脾脏和肝脏发病率。使用来自马里三个地区（ssamuou、Koulikoro和Bamako）的国家血吸虫病控制规划的独特详细纵向数据（PZQ治疗前和治疗后一年），评估吡喹酮（PZQ）治疗对这种潜在的种间血吸虫相互作用和由此导致的发病率的影响。在基线时，收集了多达2196名儿童（7-14岁）的数据，其中844名儿童仅感染了血红梭菌，124名儿童仅感染了曼氏梭菌，477名儿童同时感染了血红梭菌。随访数据从1265名儿童中收集。结果表明，混合感染的肝脏发病率低于单一感染的曼氏梭菌，混合感染的膀胱发病率高于单一感染的血红梭菌。在这些儿童中，单一的血链球菌或曼氏沙门氏菌感染也与肝脏和脾脏发病率相关，而只有单一的血链球菌感染与膀胱发病率相关（轻度血链球菌感染or: 4.3, p < 0.001，重度血链球菌感染or: 19， p < 0.001）。PZQ治疗有助于这种疾病的一些形式的回归。虽然这些观察结果的确切生物学机制仍有待确定，但结果表明，在任何寄生虫引起的发病率分析中，包括拟议的残疾调整生命年（DALYs）修订的血吸虫病发病率估计中，考虑混合物种感染的重要性。
In the developing world co-infections and polyparasitism within humans appear to be the rule rather than the exception, be it any combination of inter-specific and/or inter- and intra-Genera mixed infections. Mixed infections might generate synergistic or antagonistic interactions and thereby clinically affect individuals and/or impact parasite epidemiology. The current study uniquely assesses both Schistosoma mansoni- and Schistosoma haematobium-related morbidity of the liver and the bladder as assessed by ultrasound as well as spleen and liver morbidity through clinical exams. The impact of praziquantel (PZQ) treatment on such potential inter-specific schistosome interactions and resulting morbidity using uniquely detailed longitudinal data (pre- and one year post-PZQ treatment) arising from the National Schistosomiasis Control Program in three areas of Mali: Ségou, Koulikoro and Bamako, is also evaluated. At baseline, data were collected from up to 2196 children (aged 7-14 years), 844 of which were infected with S. haematobium only, 124 with S. mansoni only and 477 with both. Follow-up data were collected from up to 1265 children. Results suggested lower liver morbidity in mixed compared to single S. mansoni infections and higher bladder morbidity in mixed compared to single S. haematobium infections. Single S. haematobium or S. mansoni infections were also associated with liver and spleen morbidity whilst only single S. haematobium infections were associated with bladder morbidity in these children (light S. haematobium infection OR: 4.3, p < 0.001 and heavy S. haematobium infection OR: 19, p < 0.001). PZQ treatment contributed to the regression of some of the forms of such morbidities. Whilst the precise biological mechanisms for these observations remain to be ascertained, the results illustrate the importance of considering mixed species infections in any analyses of parasite-induced morbidity, including that for the proposed Disability Adjusted Life Years (DALYs) revised estimates of schistosomiasis morbidity.
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DOI：
10.4269/ajtmh.2005.73.1124
发表时间：
2005-12-01
影响因子：
3.3
作者：
Lyke, KE;Dicko, A;Doumbo, OK
通讯作者：
Doumbo, OK
影响因子：
2.7
作者：
Ernould, JC;Ba, K;Sellin, B
通讯作者：
Sellin, B
影响因子：
11.8
作者：
Levin, BR
通讯作者：
Levin, BR
DOI：
10.1016/s0035-9203(03)00070-1
发表时间：
2004-05-01
影响因子：
2.2
作者：
Garba, A;Labbo, R;Djibrilla, A
通讯作者：
Djibrilla, A
影响因子：
2.7
作者：
Coulibaly, G;Diallo, M;Keita, S
通讯作者：
Keita, S