2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.
2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.
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2009年猪 - 原素流感A(H1N1)类似于以前的流感分离株。
DOI:
10.1371/journal.pone.0006402
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发表时间:
2009-07-28
期刊:
影响因子:
3.7
通讯作者:
Salzberg SL
中科院分区:
文献类型:
--
作者:
Kingsford C;Nagarajan N;Salzberg SL
In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact. We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1). Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.
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