2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.

2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.
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2009年猪 - 原素流感A(H1N1)类似于以前的流感分离株。

DOI:
10.1371/journal.pone.0006402
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发表时间:
2009-07-28
期刊:
影响因子:
3.7
通讯作者:
Salzberg SL
Salzberg SL
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kingsford C;Nagarajan N;Salzberg SL

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2009 年 4 月,在墨西哥和美国的患者中发现了新型猪源流感病毒 (S-OIV)。这些病毒在基因上被定性为源自猪的新型甲型H1N1流感毒株,并且在很短的时间内,S-OIV毒株通过人与人之间的接触传播到全球。我们对 H1N1 猪流感分离株表面蛋白的所有可用序列进行了全面的计算搜索,发现 2000 年在泰国出现了与 S-OIV 类似的毒株。早期的分离株引起猪感染,但只有一例经测序的人类病例,A/Thailand/271/2005 (H1N1)。泰国病例和 S-OIV 病例之间的差异可能有助于揭示当前爆发菌株在人类中快速传播的能力。
In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact. We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1). Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.
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