Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis.
Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis.
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DOI：
10.1002/ajim.23313
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发表时间：
2022-03
影响因子：
3.5
通讯作者：
Teitelbaum SL
中科院分区：
文献类型：
--
作者：
Sacks HS;Smirnoff M;Carson D;Cooney ML;Shapiro MZ;Hahn CJ;Dasaro CR;Crowson C;Tassiulas I;Hirten RP;Cohen BL;Haber RS;Davies TF;Simpson DM;Crane MA;Harrison DJ;Luft BJ;Moline JM;Udasin IG;Todd AC;Sloan NL;Teitelbaum SL
世界贸易中心（WTC）一般反应队列（GRC）暴露于环境毒素，可能与发展自身免疫性疾病的风险增加有关。两项研究设计用于评估GRC中自身免疫性疾病的发病率和风险。三名经过临床培训的专业人员确定了符合诊断标准的自身免疫性疾病的可能GRC病例的状态，并根据需要由专家对同意的应答者的病历进行审查。采用条件logistic回归的巢式病例对照分析估计了与高WTC暴露（在2001年9月11日的尘云中或≥中位反应天数）相比较的低WTC暴露（所有其他GRC成员）相关的风险。在病例诊断时的年龄（±2岁）、性别、人种/种族和项目入组年份方面，将4名对照与每例病例匹配。进行了性别特异性和敏感性分析。将GRC年龄和性别校正的标准化发病率（SIR）与罗切斯特流行病学项目（REP）进行比较。由专家审查完整的REP住院和门诊病历。在≥2次访视时符合标准化标准的疾病被归类为REP确诊病例。在2002年至2017年期间，628名应答者被诊断患有自身免疫性疾病。在巢式病例对照分析中，高WTC暴露与自身免疫领域和疾病无关（风湿病领域比值比[OR] = 1.03，95%置信区间[CI] = 0.77，1.37;类风湿性关节炎OR = 1.12，95% CI = 0.70，1.77）。GRC成员的SIR低于REP。女性的风险通常大于男性。该研究发现，WTC暴露不会显著增加自身免疫性疾病的风险。
The World Trade Center (WTC) general responder cohort (GRC) was exposed to environmental toxins possibly associated with increased risk of developing autoimmune conditions. Two study designs were used to assess incidence and risks of autoimmune conditions in the GRC. Three clinically trained professionals established the status of possible GRC cases of autoimmune disorders adhering to diagnostic criteria, supplemented, as needed, by specialists’ review of consenting responders’ medical records. Nested case-control analyses using conditional logistic regression estimated the risk associated with high WTC exposure (being in the 9/11/2001 dust cloud or ≥median days' response worked) compared with low WTC exposure (all other GRC members'). Four controls were matched to each case on age at case diagnosis (±2 years), sex, race/ethnicity, and year of program enrollment. Sex-specific and sensitivity analyses were performed. GRC age- and sex-adjusted standardized incidence ratios (SIRs) were compared with the Rochester Epidemiology Project (REP). Complete REP inpatient and outpatient medical records were reviewed by specialists. Conditions meeting standardized criteria on ≥2 visits were classified as REP confirmed cases. Six hundred and twenty-eight responders were diagnosed with autoimmune conditions between 2002 and 2017. In the nested case-control analyses, high WTC exposure was not associated with autoimmune domains and conditions (rheumatologic domain odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.77, 1.37; rheumatoid arthritis OR = 1.12, 95% CI = 0.70, 1.77). GRC members had lower SIR than REP. Women's risks were generally greater than men's. The study found no statistically significant increased risk of autoimmune conditions with WTC exposures.
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影响因子：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Myasoedova, Elena;Michet, Clement J.;Ernste, Floranne C.;Warrington, Kenneth J.;Davis, John M., III;Hunder, Gene G.;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
8.9
作者：
Andersen LK;Davis MD
通讯作者：
Davis MD
影响因子：
4
作者：
Hunter, Theresa M.;Boytsov, Natalie N.;Araujo, Andre B.
通讯作者：
Araujo, Andre B.
DOI：
10.3390/ijerph16071291
发表时间：
2019-04-01
影响因子：
--
作者：
Hena, Kerry M.;Murphy, Scarlett;Reibman, Joan
通讯作者：
Reibman, Joan
影响因子：
7.7
作者：
Dasaro, Christopher R.;Holden, William L.;Todd, Andrew C.
通讯作者：
Todd, Andrew C.