Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.
Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.
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DOI：
10.1016/j.biomaterials.2014.04.004
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发表时间：
2014-07
期刊：
影响因子：
14
通讯作者：
Blower, Philip J.
中科院分区：
文献类型：
--
作者：
Cui, Xianjin;Belo, Salome;Krueger, Dirk;Yan, Yong;de Rosales, Rafael T. M.;Jauregui-Osoro, Maite;Ye, Haitao;Su, Shi;Mathe, Domokos;Kovacs, Noemi;Horvath, Ildiko;Semjeni, Mariann;Sunassee, Kavitha;Szigeti, Krisztian;Green, Mark A.;Blower, Philip J.
磁性纳米粒子(NPs)MnFe2O4和Fe3O4通过水解法沉积Al(OH)3层来稳定。该粒子在水中表现出良好的胶体稳定性，对[18F]-氟化物和双膦酸基具有很高的亲和力。核素与放射性溶液在室温下孵育5min，18F-氟化物的标记效率为97%，64Cu-双膦酸偶联物的标记效率为100.00%。颗粒的性质强烈依赖于Al(OH)3层的厚度和硬度，而Al(OH)3层的厚度和硬度又可以通过水解法进行控制。进一步探索了这些Al(OH)3包覆磁性纳米粒子在分子成像中的应用。结果表明，这些纳米粒子有可能作为磁共振和正电子发射计算机断层扫描的双模式探针。体内PET成像显示18F从NPs缓慢释放，但没有64Cu外流的迹象。
Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.
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影响因子：
16.6
作者：
de Rosales, Rafael Torres Martin;Tavare, Richard;Paul, Rowena L.;Jauregui-Osoro, Maite;Protti, Andrea;Glaria, Arnaud;Varma, Gopal;Szanda, Istvan;Blower, Philip J.
通讯作者：
Blower, Philip J.
影响因子：
13.3
作者：
Kohler, N;Sun, C;Zhang, MQ
通讯作者：
Zhang, MQ
影响因子：
4.9
作者：
Li, Shyh-Dar;Huang, Leaf
通讯作者：
Huang, Leaf
影响因子：
5.7
作者：
Pospiskova, Kristyna;Safarik, Ivo;Kuncova, Gabriela
通讯作者：
Kuncova, Gabriela
影响因子：
2.2
作者：
VIOLANTE, A;HUANG, PM
通讯作者：
HUANG, PM