Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent.
Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent.
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DOI：
10.1002/anie.201007894
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发表时间：
2011-06-06
影响因子：
16.6
通讯作者：
Blower, Philip J.
中科院分区：
文献类型：
--
作者：
de Rosales, Rafael Torres Martin;Tavare, Richard;Paul, Rowena L.;Jauregui-Osoro, Maite;Protti, Andrea;Glaria, Arnaud;Varma, Gopal;Szanda, Istvan;Blower, Philip J.
正电子发射断层扫描（PET）和磁共振成像（MRI）的协同组合很可能成为医学成像领域的下一代双模态扫描仪。得益于 PET 的灵敏且可量化的信号以及 MRI 的高软组织分辨率，这些仪器将为我们提供准确的诊断。此外，相对于当前的双模态扫描仪（例如 PET 计算机断层扫描 (CT)），患者将接受更少的辐射剂量并花费更少的时间。因此，最近人们对双模态 PET-MRI 试剂的开发越来越感兴趣。[1]迄今为止报道的大多数 PET-MRI 试剂都是基于 PET 同位素与超顺磁性氧化铁 (SPIO) 纳米粒子的组合。 [2]这些磁性纳米颗粒非常适合此目的，具有经过验证的生物相容性记录，并且在临床上作为 MRI 造影剂广泛使用，用于对网状内皮和淋巴系统进行成像。 [3]迄今为止，SPIO 的放射性标记是通过与其涂层进行复杂的化学缀合来完成的，这些涂层通常是生物相容性聚合物，例如葡聚糖，为它们提供了胶体稳定性。聚合物涂层通常与 SPIO 表面的结合相对较弱，这导致随着时间的推移缺乏稳定性。 [4]解决这个问题的一种方法是在纳米粒子表面交联聚合物单元。 [5]然而，由于合成中使用了有毒化学物质，人们对这些化合物的可翻译性存在担忧。[4b]对 SPIO 颗粒涂层进行放射性标记的另一种方法是用与 PET 同位素和纳米颗粒结合的分子直接标记其无机表面，而使聚合物涂层不受影响。在这方面，我们最近报道了用合适的同位素 (99mTc) 放射性标记的双膦酸盐 (BP；图 1)
The synergistic combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) is likely to become the next generation of dual-modality scanners in medical imaging. These instruments will provide us with accurate diagnoses thanks to the sensitive and quantifiable signal of PET and the high soft-tissue resolution of MRI. Furthermore, patients will receive less radiation dose and spend less time in the procedure relative to current dualmodality scanners (eg PET–computed tomography (CT)). As a consequence, there has been increasing interest recently in the development of dual-modality PET–MRI agents.[1] The majority of the PET–MRI agents reported to date are based on the combination of PET isotopes with superparamagnetic iron oxide (SPIO) nanoparticles.[2] These magnetic nanoparticles are ideal for the purpose, having a proven record of biocompatibility and a track record of extensive use in the clinic as MRI contrast agents for imaging the reticuloendothelial and lymphatic systems.[3] The radiolabeling of SPIOs has been done to date by often complicated chemical conjugation with their coatings, which are commonly biocompatible polymers such as dextran that provide them with colloidal stability. The polymeric coatings are typically bound relatively weakly to the surface of the SPIOs, which results in a lack of stability over time.[4] One solution to this problem is to cross-link the polymer units at the surface of the nanoparticles.[5] However, there are concerns for the translatability of these compounds due to toxic chemicals used in the synthesis.[4b]An alternative to radiolabeling the coatings of SPIO particles is to label their inorganic surface directly with a molecule that binds to both a PET isotope and the nanoparticle, leaving the polymeric coating unaffected. In this regard, we have recently reported that bisphosphonates (BPs; Figure1) radiolabeled with a suitable isotope (99mTc) for
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影响因子：
16.6
作者：
Frullano, Luca;Catana, Ciprian;Benner, Thomas;Sherry, A Dean;Caravan, Peter
通讯作者：
Caravan, Peter
影响因子：
82.9
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
4.7
作者：
Cinier, Mathieu;Petit, Marc;Tellier, Charles
通讯作者：
Tellier, Charles
影响因子：
4.6
作者：
EPSTEIN, LM;STRAUB, DK
通讯作者：
STRAUB, DK
DOI：
10.1039/b908652h
发表时间：
2009-08-28
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Torres Martin de Rosales R;Finucane C;Mather SJ;Blower PJ
通讯作者：
Blower PJ