CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation.
CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation.
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DOI：
10.1016/j.devcel.2015.03.018
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发表时间：
2015-05-26
影响因子：
11.8
通讯作者：
Sucov, Henry M.
中科院分区：
文献类型：
--
作者：
Cavallero, Susana;Shen, Hua;Yi, Christopher;Lien, Ching-Ling;Kumar, S. Ram;Sucov, Henry M.
血管丛的成熟是器官发育中一个关键但尚未完全理解的过程，已知的成熟因子在所有血管床中普遍起作用。在这项研究中，我们表明，CXCL12是一种器官特异性成熟因子，特别是在冠状动脉血管系统的相关性。在体外，CXCL12不影响新生血管的形成，但促进preinitiated血管的高阶复杂性。在心脏中，CXCL 12主要由心外膜表达，其受体CXCR 4由冠状动脉内皮细胞表达。CXCL12不是内皮细胞迁移的趋化信号，而是以旁分泌方式影响冠状血管丛的成熟。CXCL12信号转导中的突变体显示出过量的未成熟毛细血管链和动脉成熟的选择性失败，并且随着冠状动脉灌注的开始而变得渗漏。冠状动脉系统成熟失败解释了这些突变体妊娠后期的致命性。
Maturation of a vascular plexus is a critical and yet incompletely understood process in organ development, and known maturation factors act universally in all vascular beds. In this study, we show that CXCL12 is an organ-specific maturation factor of particular relevance in coronary arterial vasculature. In vitro, CXCL12 does not influence nascent vessel formation but promotes higher order complexity of preinitiated vessels. In the heart, CXCL12 is expressed principally by the epicardium and its receptor CXCR4 is expressed by coronary endothelial cells. CXCL12 is not a chemotactic signal for endothelial cell migration, but rather acts in a paracrine manner to influence the maturation of the coronary vascular plexus. Mutants in CXCL12 signaling show an excess of immature capillary chains and a selective failure in arterial maturation, and become leaky with the onset of coronary perfusion. Failed maturation of the coronary system explains the late-gestation lethality of these mutants.
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影响因子：
3.8
作者：
Santiago, Begona;Calonge, Esther;Pablos, Jose L.
通讯作者：
Pablos, Jose L.
影响因子：
10.5
作者：
Siekmann, Arndt F.;Standley, Clive;Lawson, Nathan D.
通讯作者：
Lawson, Nathan D.
影响因子：
4.7
作者：
Nagasawa, Takashi
通讯作者：
Nagasawa, Takashi
DOI：
10.1073/pnas.95.16.9448
发表时间：
1998-08-04
影响因子：
11.1
作者：
Ma, Q;Jones, D;Springer, TA
通讯作者：
Springer, TA
影响因子：
10.8
作者：
Shen, Hua;Cavallero, Susana;Sucov, Henry M.
通讯作者：
Sucov, Henry M.