Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknowns.
Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknowns.
复制标题
DOI：
10.1016/j.apsb.2021.09.005
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Arteel GE
中科院分区：
文献类型：
--
作者：
Beier JI;Arteel GE
肝脏疾病被认为主要具有遗传性或外源性病因。然而，遗传驱动了适当适应环境压力的能力，疾病是适应不良反应的高潮。因此，“纯”遗传性和“纯”外源性肝病是由彼此和其他因素，确定或未知的修改。本综述的目的是强调环境暴露作为其他原因导致肝病发展的潜在风险调节剂的知识基础。这项工作并不是说所有的肝病都有环境因素，而是挑战这样一个假设，即我们目前的知识水平足以在所有情况下最终排除这种可能性。本次审查还讨论了未来可能对解决这一问题至关重要的关键新工具和方法。总的来说，确定我们理解中的关键差距对于该领域的发展至关重要，或者至少是“知道我们不知道的”。肝损伤和疾病有主要的潜在原因。肝病还受到影响严重程度和结局的合并症的影响。此外，风险修正因素（例如，“麻烦”）影响个体间易感性。
Liver diseases are considered to predominantly possess an inherited or xenobiotic etiology. However, inheritance drives the ability to appropriately adapt to environmental stressors, and disease is the culmination of a maladaptive response. Thus “pure” genetic and “pure” xenobiotic liver diseases are modified by each other and other factors, identified or unknown. The purpose of this review is to highlight the knowledgebase of environmental exposure as a potential risk modifying agent for the development of liver disease by other causes. This exercise is not to argue that all liver diseases have an environmental component, but to challenge the assumption that the current state of our knowledge is sufficient in all cases to conclusively dismiss this as a possibility. This review also discusses key new tools and approaches that will likely be critical to address this question in the future. Taken together, identifying the key gaps in our understanding is critical for the field to move forward, or at the very least to “know what we don't know.” Liver injury and disease have primary underlying causes. Liver disease is also impacted by comorbities that influence the severity and outcome. Moreover, risk modifiers (e.g., “exposome”) influence interindividual susceptibility.
登录
查看更多内容
影响因子：
3.8
作者：
Beggs KM;McGreal SR;McCarthy A;Gunewardena S;Lampe JN;Lau C;Apte U
通讯作者：
Apte U
影响因子：
1.5
作者：
Al-Eryani L;Wahlang B;Falkner KC;Guardiola JJ;Clair HB;Prough RA;Cave M
通讯作者：
Cave M
影响因子：
13.5
作者：
Cave, Matt;Falkner, Keith Cameron;Ray, Mukunda;Joshi-Barve, Swati;Brock, Guy;Khan, Rehan;Homme, Marjorie Bon;McClain, Craig J.
通讯作者：
McClain, Craig J.
影响因子：
25.7
作者：
Asrani, Sumeet K.;Devarbhavi, Harshad;Kamath, Patrick S.
通讯作者：
Kamath, Patrick S.
影响因子：
1.9
作者：
Bergquist, Annika;Said, Karouk;Broome, Ulrika
通讯作者：
Broome, Ulrika