Biosynthesis, enzymology, and future of eunicellane diterpenoids.
Biosynthesis, enzymology, and future of eunicellane diterpenoids.
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DOI：
10.1093/jimb/kuad027
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发表时间：
2023-02-17
影响因子：
3.4
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中科院分区：
文献类型：
--
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Eunicellane 二萜类化合物是一个非凡的萜烯天然产物家族，五十多年来一直受到人们的高度关注。尤尼塞烷广泛分布于软珊瑚中，在植物中很少见，最近也在放线菌中被发现。这些萜类化合物具有基本的 6/10 双环骨架，经常被氧化成含有跨环醚桥的结构。人们对其独特的结构和有前途的生物活性（例如刺五加素和肉毒素的紫杉醇样活性）的兴趣导致了天然产物分离、全合成、药物化学和先导药物开发方面的进步。然而，直到最近，人们对这些天然产物的生物合成和酶学知之甚少，但最近对细菌和珊瑚的几项研究开辟了这一领域。该综述总结了单胞二萜生物合成和酶学的最新进展，并强调了该领域的未来研究前景。总结了单胞二萜生物合成和酶学的最新进展，二萜是在珊瑚、植物和细菌中发现的结构独特且具有生物活性的天然产物家族。细菌和珊瑚中单胞菌烷的生物合成，突出了萜烯合酶衍生骨架和功能化天然产物的结构多样性。
Eunicellane diterpenoids are a remarkable family of terpene natural products and have been of high interest for over five decades. Widely distributed in soft corals and rare in plants, eunicellanes were also recently identified in actinobacteria. These terpenoids have foundational 6/10-bicyclic frameworks that are frequently oxidized into structures containing transannular ether bridges. Interest in their unique structures and promising biological activities, such as the paclitaxel-like activities of eleutherobin and the sarcodictyins, has led to advancements in natural product isolation, total synthesis, medicinal chemistry, and drug lead development. Until recently, however, there was little known about the biosynthesis and enzymology of these natural products, but several recent studies in both bacteria and coral have opened up the field. This review summarizes recent advancements in the biosynthesis and enzymology of eunicellane diterpenoids and highlights future research prospects in the field. A summary of recent advancements in the biosynthesis and enzymology of eunicellane diterpenoids, a structurally unique and biologically active family of natural products found in coral, plants, and bacteria. Biosynthesis of eunicellanes in bacteria and coral, highlighting the structural diversity of the terpene synthase-derived skeletons and the functionalized natural products.
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