Bacterial terpenome.
Bacterial terpenome.
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DOI：
10.1039/d0np00066c
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发表时间：
2021-05-26
影响因子：
11.9
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Rudolf JD;Alsup TA;Xu B;Li Z
萜类化合物，也称为类异戊二烯，是天然产物中最大和结构最多样的家族。在生命的各个领域都有发现，已知的化合物超过8万种。大多数特征化的萜类化合物，包括一些最熟知的、药学上相关的和商业上有价值的天然产物，由植物和真菌产生。细菌来源的萜类化合物相对较少。这与最近的微生物基因组学揭示的事实相反，几乎所有的细菌都具有生物合成潜力来产生萜类化合物生物合成所必需的C5构件。在这篇综述中，我们目录萜类化合物产生的细菌。我们收集了1062个天然产物，包括初级和次级代谢产物，并将其分为两个主要家族和55个不同的亚科。为了突出细菌萜类化合物的结构和化学空间，我们讨论了它们的结构，生物合成和生物活性。虽然细菌萜类相对较小，但它为未来的研究提供了一个迷人的二分法。细菌和非细菌萜类化合物及其生物合成途径之间的相似性为详细表征提供了替代模型系统，而丰富的新骨架，生物合成途径和生物活性为药物发现，基因组挖掘和酶学提供了新的机会。我们突出了细菌萜类化合物的现状，强调这些萜类天然产物的发现，结构，生物合成途径和生物活性。
Terpenoids, also called isoprenoids, are the largest and most structurally diverse family of natural products. Found in all domains of life, there are over 80,000 known compounds. The majority of characterized terpenoids, which include some of the most well known, pharmaceutically relevant, and commercially valuable natural products, are produced by plants and fungi. Comparatively, terpenoids of bacterial origin are rare. This is counter-intuitive to the fact that recent microbial genomics revealed that almost all bacteria have the biosynthetic potential to create the C5 building blocks necessary for terpenoid biosynthesis. In this review, we catalogue terpenoids produced by bacteria. We collected 1062 natural products, consisting of both primary and secondary metabolites, and classified them into two major families and 55 distinct subfamilies. To highlight the structural and chemical space of bacterial terpenoids, we discuss their structures, biosynthesis, and biological activities. Although the bacterial terpenome is relatively small, it presents a fascinating dichotomy for future research. Similarities between bacterial and non-bacterial terpenoids and their biosynthetic pathways provides alternative model systems for detailed characterization while the abundance of novel skeletons, biosynthetic pathways, and bioactivies presents new opportunities for drug discovery, genome mining, and enzymology. We highlight the current state of the bacterial terpenome, emphasizing the discoveries, structures, biosynthetic pathways, and biological activities of these terpenoid natural products.
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影响因子：
3.2
作者：
Alqahtani, Norah;Porwal, Suheel K.;Viswanathan, Rajesh
通讯作者：
Viswanathan, Rajesh
影响因子：
4
作者：
Annaval, Thibault;Han, Lu;Shen, Ben
通讯作者：
Shen, Ben
DOI：
10.1073/pnas.81.19.5994
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AKIYOSHI, DE;KLEE, H;GORDON, MP
通讯作者：
GORDON, MP
影响因子：
3
作者：
Aguero, J;Lora, J;Pino, JA
通讯作者：
Pino, JA
影响因子：
3.3
作者：
AOYAGI, T;AOYAMA, T;TAKEUCHI, T
通讯作者：
TAKEUCHI, T