More Than Just a Weed: An Exploration of the Antimicrobial Activity of Rumex crispus using a Multivariate Data Analysis Approach.
More Than Just a Weed: An Exploration of the Antimicrobial Activity of Rumex crispus using a Multivariate Data Analysis Approach.
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作者：
植物因其药用特性而被使用的历史很长。植物提取物的复杂性提出了独特的挑战，需要应用创新的方法来正确识别和量化生物活性化合物。在这项研究中，我们采用非靶向代谢组学方法来探索黄码头（Rumex crispus）的抗菌活性，黄码头是蓼科植物中的一员，被用作治疗细菌感染的草药。采用超高效液相色谱-高分辨质谱法（UPLC-MS）对已知抗菌化合物大黄素进行鉴定和定量。此外，我们采用生物化学计量学方法，将测量crispr根起始材料和组分对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性的数据与UPLC-MS数据进行整合。我们的研究结果支持了多种成分，包括蒽醌大黄素，对crispus对MRSA的抗菌活性有贡献的假设。
Plants have a long history of use for their medicinal properties. The complexity of botanical extracts presents unique challenges and necessitates the application of innovative approaches to correctly identify and quantify bioactive compounds. With this study, we employed untargeted metabolomics to explore the antimicrobial activity of Rumex crispus (yellow dock), a member of the Polygonaceae family that is used as an herbal remedy for bacterial infections. Ultra-performance liquid chromatography coupled to high resolution mass-spectrometry (UPLC-MS) was used to identify and quantify the known antimicrobial compound emodin. In addition, we used biochemometric approaches to integrate data measuring antimicrobial activity from R. crispus root starting material and fractions against methicillin-resistant Staphylococcus aureus (MRSA) with UPLC-MS data. Our results support the hypothesis that multiple constituents, including the anthraquinone emodin, contribute to the antimicrobial activity of R. crispus against MRSA.
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影响因子：
3.4
作者：
Orban-Gyapai, Orsolya;Liktor-Busa, Erika;Vasas, Andrea
通讯作者：
Vasas, Andrea
DOI：
10.1016/j.ijmm.2013.02.007
发表时间：
2013-08
期刊：
International journal of medical microbiology : IJMM
影响因子：
--
作者：
Otto M
通讯作者：
Otto M
影响因子：
7.4
作者：
Caesar, Lindsay K.;Nogo, Sabina;Cech, Nadja B.
通讯作者：
Cech, Nadja B.
影响因子：
1.3
作者：
Piola, Florence;Bellvert, Floriant;Bertrand, Cedric
通讯作者：
Bertrand, Cedric
影响因子：
5.1
作者：
Kellogg, Joshua J.;Todd, Daniel A.;Egan, Joseph M.;Raja, Huzefa A.;Oberlies, Nicholas H.;Kvalheim, Olav M.;Cech, Nadja B.
通讯作者：
Cech, Nadja B.