The clinical implications of serum ferritin in Kawasaki disease: a helpful biomarker for evaluating therapeutic responsiveness, coronary artery involvement and the tendency of macrophage activation syndrome.
The clinical implications of serum ferritin in Kawasaki disease: a helpful biomarker for evaluating therapeutic responsiveness, coronary artery involvement and the tendency of macrophage activation syndrome.
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DOI：
10.5114/aoms/144293
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hu P
中科院分区：
文献类型：
--
作者：
Qiu Z;Liu HH;Fan GZ;Chen WX;Hu P
血清铁蛋白（SF）是炎症性疾病中的急性相反应物。
将244个KD儿童分为6个亚组。
（1）SF在KD的急性阶段大幅增加，并在IVIG治疗后保持SF； ％;（3）SF增加了4例巨噬细胞综合征（MAS）/MAS趋势（979.03±474.19μg/L）。
SF暗示是预测IVIG非反应KD，冠状动脉异常（CAAS）和MAS趋势的有用生物标志物。
Serum ferritin (SF) is an acute-phase reactant in inflammatory diseases. Our aim was to analyze the clinical implications of SF in Kawasaki disease (KD). 244 KD children were divided into 6 subgroups. SF, inflammatory mediators and blood cell counts were detected. (1) SF dramatically increased in the acute phase of KD and maintained after IVIG therapy; (2) SF increased in IVIG-nonresponsive KD patients (AUC = 0.705; sensitivity: 57.10%; specificity: 82.90%); SF positively correlated with the internal diameter of the coronary artery (AUC = 0.603; sensitivity: 92.30%; specificity: 37.70%); (3) SF increased in 4 patients with the macrophage activation syndrome (MAS)/MAS tendency (979.03 ±474.19 μg/l). SF is implied to be a helpful biomarker for forecasting IVIG-nonresponsive KD, coronary artery abnormalities (CAAs) and MAS tendency.
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