Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.
Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.
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DOI：
10.1016/j.jnutbio.2009.01.020
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Mattson MP
中科院分区：
文献类型：
--
作者：
Wan R;Ahmet I;Brown M;Cheng A;Kamimura N;Talan M;Mattson MP
据报道，饮食能量限制，包括间歇性禁食（IF），可以保护心脏和脑细胞免受损伤，并改善心肌梗死和中风动物模型的功能结果。在这里，我们报告说，IF改善血糖控制和保护心肌缺血引起的细胞损伤和炎症大鼠。心脏结构和功能变量的超声心动图分析显示，IF减弱了与生长相关的后心室壁厚度、收缩末期和舒张末期容积的增加，并降低了射血分数。永久结扎冠状动脉后24小时缺血性梗死的大小显着较小，炎症标志物（白细胞浸润的风险和血浆IL-6水平的区域）较少，在IF大鼠与对照饮食的大鼠相比。IF导致心肌梗死前后循环脂联素水平升高。由于最近的研究表明，脂联素可以保护心脏免受缺血性损伤，我们的研究结果表明，脂联素作为IF的心脏保护作用的介质的潜在作用。
It has been reported that dietary energy restriction, including intermittent fasting (IF), can protect heart and brain cells against injury and improve functional outcome in animal models of myocardial infarction and stroke. Here we report that IF improves glycemic control and protects the myocardium against ischemia-induced cell damage and inflammation in rats. Echocardiographic analysis of heart structural and functional variables revealed that IF attenuates the growth-related increase in posterior ventricular wall thickness, , end systolic and diastolic volumes, and reduces the ejection fraction. The size of the ischemic infarct 24 hours following permanent ligation of a coronary artery was significantly smaller, and markers of inflammation (infiltration of leukocytes in the area at risk and plasma IL-6 levels) were less, in IF rats compared to rats on the control diet. IF resulted in increased levels of circulating adiponectin prior to and after myocardial infarction. Because recent studies have shown that adiponectin can protect the heart against ischemic injury, our findings suggest a potential role for adiponectin as a mediator of the cardioprotective effect of IF.
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