Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass.
Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass.
复制标题
作者：
Groom A;Potter C;Swan DC;Fatemifar G;Evans DM;Ring SM;Turcot V;Pearce MS;Embleton ND;Smith GD;Mathers JC;Relton CL
Rapid postnatal growth is associated with increased risk of childhood adiposity. The aim of this study was to establish whether this pathway is mediated by altered DNA methylation and gene expression. Two distinct cohorts, one preterm (n = 121) and one term born (n = 6,990), were studied. Exploratory analyses were performed using microarrays to identify differentially expressed genes in whole blood from children defined as “slow” (n = 10) compared with “rapid” (n = 10) postnatal (term to 12 weeks corrected age) growers. Methylation within the identified TACSTD2 gene was measured in both cohorts, and rs61779296 genotype was determined by Pyrosequencing or imputation and analyzed in relation to body composition at 9–15 years of age. In cohort 1, TACSTD2 expression was inversely correlated with methylation (P = 0.016), and both measures were associated with fat mass (expression, P = 0.049; methylation, P = 0.037). Although associated with gene expression (cohort 1, P = 0.008) and methylation (cohort 1, P = 2.98 × 10−11; cohort 2, P = 3.43 × 10−15), rs61779296 was not associated with postnatal growth or fat mass in either cohort following multiple regression analysis. Hence, the lack of association between fat mass and a methylation proxy SNP suggests that reverse causation or confounding may explain the initial association between fat mass and gene regulation. Noncausal methylation patterns may still be useful predictors of later adiposity.
登录
查看更多内容
影响因子：
5.2
作者：
Jones, RW;Ring, S;Golding, J
通讯作者：
Golding, J
DOI：
10.1007/978-1-4020-9173-5_13
发表时间：
2009-01-01
期刊：
EARLY NUTRITION PROGRAMMING AND HEALTH OUTCOMES IN LATER LIFE: OBESITY AND BEYOND
影响因子：
--
作者：
Mathers, John C.;Mckay, Jill A.
通讯作者：
Mckay, Jill A.
影响因子：
2.8
作者：
Fang, Y. J.;Lu, Z. H.;Wan, D. S.
通讯作者：
Wan, D. S.
影响因子：
37.3
作者：
Cubas R;Zhang S;Li M;Chen C;Yao Q
通讯作者：
Yao Q
影响因子：
7.7
作者：
Godfrey KM;Sheppard A;Gluckman PD;Lillycrop KA;Burdge GC;McLean C;Rodford J;Slater-Jefferies JL;Garratt E;Crozier SR;Emerald BS;Gale CR;Inskip HM;Cooper C;Hanson MA
通讯作者：
Hanson MA