Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms.
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms.
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DOI：
10.1146/annurev-genet-110410-132541
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发表时间：
2011
影响因子：
11.1
通讯作者：
Lin H
中科院分区：
文献类型：
--
作者：
Juliano C;Wang J;Lin H
生殖系的多能性是胚胎干细胞和成体干细胞多能性和多能性的充分体现，因此生殖系和干细胞必须具有共同的机制来保证它们在发育中的多能性。Piwi蛋白是为数不多的已知共享机制之一，它构成了Argonaute蛋白家族的两个亚家族之一。Piwi蛋白与Piwi相互作用rna （pirna）结合，通常长度为26-31个核苷酸。Piwi蛋白和pirna都在种系中大量表达。此外，Piwi蛋白在某些类型的体细胞干/祖细胞和其他动物系统发育的体细胞中广泛表达。最近的研究表明，Piwi-piRNA通路介导表观遗传编程和转录后调控，可能在多种生物的种系规范、配子体发生、干细胞维持、转座子沉默和基因组完整性中发挥作用。
The topipotency of the germline is the full manifestation of the pluri- and multipotency of embryonic and adult stem cells, thus the germline and stem cells must share common mechanisms that guarantee their multipotentials in development. One of the few such known shared mechanisms is represented by Piwi proteins, which constitute one of the two subfamilies of the Argonaute protein family. Piwi proteins bind to Piwi-interacting RNAs (piRNAs) that are generally 26–31 nucleotides in length. Both Piwi proteins and piRNAs are most abundantly expressed in the germline. Moreover, Piwi proteins are expressed broadly in certain types of somatic stem/progenitor cells and other somatic cells across animal phylogeny. Recent studies indicate that the Piwi-piRNA pathway mediates epigenetic programming and post-transcriptional regulation, which may be responsible for its function in germline specification, gametogenesis, stem cell maintenance, transposon silencing, and genome integrity in diverse organisms.
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DOI：
10.1002/jez.b.21303
发表时间：
2009-12-15
影响因子：
2.2
作者：
Brown, Federico D.;Keeling, Elena L.;Swalla, Billie J.
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
2009-12-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
64.5
作者：
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