Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study.
Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study.
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1型和2型糖尿病青年糖尿病周围神经病的患病率和危险因素：青年研究中寻找糖尿病。
DOI：
10.2337/dc17-0179
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发表时间：
2017-09
期刊：
影响因子：
16.2
通讯作者：
Feldman EL
中科院分区：
文献类型：
--
作者：
Jaiswal M;Divers J;Dabelea D;Isom S;Bell RA;Martin CL;Pettitt DJ;Saydah S;Pihoker C;Standiford DA;Dolan LM;Marcovina S;Linder B;Liese AD;Pop-Busui R;Feldman EL
我们评估了参加青少年糖尿病搜索 (SEARCH) 研究的 1 型糖尿病 (T1D) 和 2 型糖尿病 (T2D) 青少年糖尿病周围神经病变 (DPN) 的患病率和危险因素。使用密歇根神经病变筛查仪器 (MNSI) 评估 1,734 名 T1D 青少年（平均 ± 标准差，年龄 18 ± 4 岁，T1D 持续时间 7.2 ± 1.2 年，HbA1c 9.1 ± 1.9%）和 258 名 T2D 青少年（年龄 22 ± 3.5 岁，T2D 持续时间 7.9 ± 2 年，HbA1c）的 DPN 9.4± 2.3%）参加了 SEARCH 研究且糖尿病病程≥5 年。 DPN 被定义为 MSI 考试成绩 >2。随着时间的推移，血糖控制被估计为 HbA1c 曲线下面积。 1 型糖尿病青少年中 DPN 的患病率为 7%，2 型糖尿病青少年中 DPN 的患病率为 22%。患有 T1D 的青少年发生 DPN 的危险因素包括年龄较大、糖尿病病程较长、吸烟、舒张压升高、肥胖、低密度脂蛋白胆固醇和甘油三酯升高以及高密度脂蛋白胆固醇 (HDL-c) 降低。在患有 T2D 的青少年中，危险因素包括年龄较大、男性、糖尿病病程较长、吸烟和 HDL-c 较低。与未患有 DPN 的 T1D 青少年相比，随着时间的推移，患有 DPN 的患者血糖控制较差（比值比 1.53 [95% CI 1.24; 1.88]），但 T2D 青少年则不然（1.05 [0.7; 1.56]）。患有糖尿病的青少年中 DPN 的高发病率令人担忧，并表明需要早期筛查和更好的危险因素管理。针对青少年血糖控制不良和血脂异常的干预措施可以预防或延缓使人衰弱的神经性并发症。
We assessed the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in the SEARCH for Diabetes in Youth (SEARCH) study. The Michigan Neuropathy Screening Instrument (MNSI) was used to assess DPN in 1,734 youth with T1D (mean ± SD age 18 ± 4 years, T1D duration 7.2 ± 1.2 years, and HbA1c 9.1 ± 1.9%) and 258 youth with T2D (age 22 ± 3.5 years, T2D duration 7.9 ± 2 years, and HbA1c 9.4 ± 2.3%) who were enrolled in the SEARCH study and had ≥5 years of diabetes duration. DPN was defined as an MNSI exam score of >2. Glycemic control over time was estimated as area under the curve for HbA1c. The prevalence of DPN was 7% in youth with T1D and 22% in youth with T2D. Risk factors for DPN in youth with T1D were older age, longer diabetes duration, smoking, increased diastolic blood pressure, obesity, increased LDL cholesterol and triglycerides, and lower HDL cholesterol (HDL-c). In youth with T2D, risk factors were older age, male sex, longer diabetes duration, smoking, and lower HDL-c. Glycemic control over time was worse among those with DPN compared with those without for youth with T1D (odds ratio 1.53 [95% CI 1.24; 1.88]) but not for youth with T2D (1.05 [0.7; 1.56]). The high rates of DPN among youth with diabetes are a cause of concern and suggest a need for early screening and better risk factor management. Interventions in youth that address poor glycemic control and dyslipidemia may prevent or delay debilitating neuropathic complications.
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影响因子：
16.2
作者：
Eppens, Maike C.;Craig, Maria E.;Donaghue, Kim C.
通讯作者：
Donaghue, Kim C.
影响因子：
5.1
作者：
Kershnar, Ann K.;Daniels, Stephen R.;Rodriguez, Beatriz L.
通讯作者：
Rodriguez, Beatriz L.
影响因子：
3.5
作者：
Olsen, BS;Johannesen, J;Mortensen, HB
通讯作者：
Mortensen, HB
影响因子：
168.9
作者：
Turner, RC;Holman, RR;Ward, JD
通讯作者：
Ward, JD
影响因子：
120.7
作者：
Dabelea, Dana;Mayer-Davis, Elizabeth J.;Saydah, Sharon;Imperatore, Giuseppina;Linder, Barbara;Divers, Jasmin;Bell, Ronny;Badaru, Angela;Talton, Jennifer W.;Crume, Tessa;Liese, Angela D.;Merchant, Anwar T.;Lawrence, Jean M.;Reynolds, Kristi;Dolan, Lawrence;Liu, Lenna L.;Hamman, Richard F.
通讯作者：
Hamman, Richard F.