Vasomotor symptoms and coronary artery calcium in postmenopausal women.
Vasomotor symptoms and coronary artery calcium in postmenopausal women.
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DOI：
10.1097/gme.0b013e3181e664dc
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Woods NF
中科院分区：
文献类型：
--
作者：
Allison MA;Manson JE;Aragaki A;Langer RD;Rossouw J;Curb D;Martin LW;Phillips L;Stefanick ML;Cochrane BB;Sarto G;Barnhart J;O'Sullivan MJ;Johnson KC;Gass M;Trevisan M;Woods NF
We assessed whether vasomotor symptoms (VMS) were associated with coronary artery calcium (CAC) and how hormone therapy may influence this association. Subjects were a subset of women aged 50 to 59 and a history of hysterectomy that enrolled in the Women’s Health Initiative (WHI) clinical trial of estrogen alone and underwent a computed tomography scan of the chest at the end of the trial to determine CAC. Participants provided information about VMS (hot flashes and/or night sweats), as well as HT use, on self-administered questionnaires at trial baseline. The sample consisted of 918 women with a mean (SD) age of 55.1 (2.8) years at WHI randomization and 64.8 (2.9) years at CAC ascertainment. The prevalence of a CAC score > 0 was 46%, while the prevalence of a CAC score ≥ 10 and > 100 was 39 and 19%, respectively. At randomization, 77% reported a history of any VMS at any time prior to or at enrollment in the WHI while 20% reported any VMS only present at enrollment. Compared to those without a history of any VMS and after adjustment for potential confounders, a history of any VMS at any time up to and including WHI enrollment was associated with a significantly reduced odds for CAC > 0 (Odds Ratio 0.66, 95% CI 0.45 – 0.98). Moreover, as duration of HT increased the inverse association between any VMS and CAC moved toward the null. A history of any VMS was significantly associated with a reduced odds for CAC independent of traditional CVD risk factors and other relevant covariates. This association appears to be influenced by duration of hormone therapy.
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影响因子：
7.2
作者：
Guthrie, JR;Dennerstein, L;Burger, HG
通讯作者：
Burger, HG
影响因子：
8.7
作者：
Dhore, CR;Cleutjens, JPM;Daemen, MJAP
通讯作者：
Daemen, MJAP
影响因子：
7.2
作者：
Barnabei, VM;Grady, D;Pickar, JH
通讯作者：
Pickar, JH
影响因子：
5.6
作者：
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通讯作者：
Prentice, RL
影响因子：
3.5
作者：
Allison, MA;Wright, CM
通讯作者：
Wright, CM