What Does Sex Have to Do with It? The Role of Sex as a Biological Variable in the Development of Posttraumatic Stress Disorder.
What Does Sex Have to Do with It? The Role of Sex as a Biological Variable in the Development of Posttraumatic Stress Disorder.
复制标题
DOI：
10.1007/s11920-018-0907-x
复制
发表时间：
2018-05-18
影响因子：
6.7
通讯作者：
Epperson CN
中科院分区：
文献类型：
--
作者：
Kornfield SL;Hantsoo L;Epperson CN
This review highlights the neurobiological aspects of sex differences in posttraumatic stress disorder (PTSD), specifically focusing on the physiological responses to trauma and presents evidence supporting hormone and neurosteroid/peptide differences from both preclinical and clinical research. While others have suggested that trauma type or acute emotional reaction are responsible for women’s disproportionate risk to PTSD, neither of these explanations fully accounts for the sex differences in PTSD. Sex differences in brain neurocircuitry, anatomy, and neurobiological processes, such as those involved in learning and memory, are discussed as they have been implicated in risk and resilience for the development of PTSD. Gonadal and stress hormones have been found to modulate sex differences in the neurocircuitry and neurochemistry underlying fear learning and extinction. Preclinical research has not consistently controlled for hormonal and reproductive status of rodents nor have clinical studies consistently examined these factors as potential moderators of risk for PTSD. Sex as a biological variable (SABV) should be considered, in addition to the endocrine and reproductive status of participants, in all stress physiology and PTSD research.
登录
查看更多内容
与压力有关的精神疾病的性别差异：神经生物学观点。
影响因子：
7.4
作者：
Bangasser, Debra A.;Valentino, Rita J.
通讯作者：
Valentino, Rita J.
影响因子：
1.9
作者：
Ahern, J;Galea, S;Vlahov, D
通讯作者：
Vlahov, D
影响因子：
3.5
作者：
Chang, Yao-Ju;Yang, Chih-Hao;Hsu, Kuei-Sen
通讯作者：
Hsu, Kuei-Sen
影响因子：
1.6
作者：
Beck, Kevin D.;McLaughlin, Joselyn;Servatius, Richard J.
通讯作者：
Servatius, Richard J.
影响因子：
7.2
作者：
Dumas, Julie A.;Albert, Kimberly M.;Newhouse, Paul A.
通讯作者：
Newhouse, Paul A.