A critical review of genetic studies of schizophrenia. I. Epidemiological and brain studies

A critical review of genetic studies of schizophrenia. I. Epidemiological and brain studies
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精神分裂症遗传学研究的批判性回顾。

DOI:
10.1111/j.1600-0447.1997.tb00365.x
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发表时间:
1997
影响因子:
6.7
通讯作者:
Y. Alanen
Y. Alanen
中科院分区:
医学1区
文献类型:
--
作者:
P. Portin;Y. Alanen

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家庭、双胞胎和收养研究表明,精神分裂症的易感性至少在一定程度上取决于基因。这些研究的结果各不相同,并在很大程度上取决于所使用的诊断标准。当采用精神分裂症的广义定义时,甚至可以观察到高度的遗传性。然而,当采用更窄的标准时,遗传度降低。根据芬兰的一项大型收养研究,患者-家庭互动在精神分裂症的起源中比纯粹的遗传因素更重要。一方面强调遗传因素与另一方面强调生理、心理和社会心理因素之间的相互作用。
Family, twin and adoption studies suggest that susceptibility to schizophrenia is based at least to some extent on genes. The results of these studies vary and depend greatly on the diagnostic criteria used. When a broad definition of schizophrenia is employed, even high degrees of heritability are observed. However, when more narrow criteria are employed, the degrees of heritability decrease. According to a large Finnish adoption study, the patient‐family interaction has an even more important role in the origin of schizophrenia than purely genetic factors. Interaction between the genetic factors on the one hand and physical, psychological and psychosocial factors on the other hand is emphasized.
DOI: 10.1176/ajp.149.7.890
发表时间: 1992-07
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影响因子: --
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