Association of sleep apnoea risk and aortic enlargement in Marfan syndrome.
Association of sleep apnoea risk and aortic enlargement in Marfan syndrome.
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DOI：
10.1136/bmjresp-2021-000942
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发表时间：
2021-11
影响因子：
4.1
通讯作者：
Neptune ER
中科院分区：
文献类型：
--
作者：
Sowho M;MacCarrick G;Dietz H;Jun J;Schwartz AR;Neptune ER
马凡氏综合征（MFS）是一种结缔组织疾病，其特征是复杂的主动脉病理和阻塞性睡眠呼吸暂停（OSA）的高患病率。OSA产生胸内透壁应力，可加速主动脉损伤。目前的研究旨在检查OSA风险与MFS主动脉扩张标志物之间的相关性。在约翰霍普金斯招募符合条件的MFS患者，如果他们完成了STOP-BANG调查。综合调查评分分为低OSA风险（STOP-BANG <3）和高OSA风险（STOP-BANG ≥ 3）。对参与者的主动脉数据进行整理，以确定主动脉根部直径、扩张和既往主动脉根部置换术。回归分析用于检查OSA风险分层和这些主动脉参数之间的关联。在研究的89名参与者中，28%的人有高OSA风险，32%的人有主动脉移植物。与低OSA风险者相比，高OSA风险者的主动脉根部直径（mm）（λ = 4.13，SE = 1.81，p = 0.027）和主动脉根部扩张（λ = 2.80，SE = 1.34，p = 0.046）更大。此外，与低OSA风险患者相比，高OSA风险患者既往接受主动脉根部置换术的几率高3倍。在MFS中，高OSA风险与主动脉增大相关，并且既往接受过主动脉根部置换的风险增加3倍。这些发现促使进一步探索MFS中OSA和主动脉疾病之间的关系，并研究阐明OSA的靶向干预是否可能减轻MFS中主动脉疾病的进展。IRB00157483。
Marfan syndrome (MFS) is a connective tissue disorder characterised by complex aortic pathology and a high prevalence of obstructive sleep apnoea (OSA). OSA produces intrathoracic transmural stresses that may accelerate aortic injury. The current study was designed to examine the associations between OSA risk and markers of aortic enlargement in MFS. Consecutive patients with MFS were recruited at Johns Hopkins if they completed a STOP-BANG survey. Composite survey scores were categorised into those with low OSA risk (STOP-BANG <3) and high OSA risk (STOP-BANG ≥3). Participants’ aortic data were collated to ascertain aortic root diameter, dilatation and prior aortic root replacement. Regression analyses were used to examine associations between OSA risk strata and these aortic parameters. Of the 89 participants studied, 28% had a high OSA risk and 32% had aortic grafts. Persons with high OSA risk had greater aortic root diameter (mm) (ß=4.13, SE=1.81, p=0.027) and aortic root dilatation (ß=2.80, SE=1.34, p=0.046) compared with those with low OSA risk. In addition, the odds of prior aortic root replacement was three times greater in those with high OSA risk compared with those with low OSA risk. In MFS, high OSA risk is associated with aortic enlargement and a threefold increased risk of having had prior aortic root replacement. These findings invite further exploration of the relationship between OSA and aortic disease in MFS, and studies to clarify whether targeted interventions for OSA might mitigate aortic disease progression in MFS. IRB00157483.
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影响因子：
4
作者：
Barrios P;Martin-Biggers J;Quick V;Byrd-Bredbenner C
通讯作者：
Byrd-Bredbenner C
DOI：
10.1164/ajrccm/147.3.645
发表时间：
1993-03-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
CISTULLI, PA;SULLIVAN, CE
通讯作者：
SULLIVAN, CE
影响因子：
3.7
作者：
Kohler, Malcolm;Pitcher, Alex;Stradling, John R.
通讯作者：
Stradling, John R.
影响因子：
3.7
作者：
Narkiewicz, Krzysztof;Wolf, Jacek;Somers, Virend K
通讯作者：
Somers, Virend K
影响因子：
--
作者：
Roman, Mary J.;Devereux, Richard B.;Weinsaft, Jonathan W.
通讯作者：
Weinsaft, Jonathan W.