Cold acclimation of obese (ob/ob) mice: effects of energy balance.
Cold acclimation of obese (ob/ob) mice: effects of energy balance.
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肥胖（ob/ob）小鼠的冷适应：能量平衡的影响。
DOI：
10.1016/0026-0495(84)90114-8
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Romsos,DR
中科院分区：
文献类型：
--
作者：
Smith,CK;Romsos,DR
将4周龄的肥胖（ob ob）和瘦小鼠在23° C或14° C下饲养4至8周，以检查适应轻度寒冷对能量平衡的影响。在14° C下饲养时，年轻瘦小鼠的能量摄入增加了约50%，但冷适应肥胖小鼠的能量摄入仅增加了8%。肥胖小鼠的能量保持效率（能量获得与能量摄入的比率）从23° C下的22%±1.2%下降到14° C下4周后的10%±1.8%。瘦小鼠对温度的反应不太明显;它们的能量保留效率从23° C的7%±1.3%下降到14° C 4周后的4%±2.2%。经过8周的冷暴露，肥胖和瘦小鼠的体重和能量保持效率变得相等。冷适应的肥胖和瘦小鼠的计算产热比各自的对照组高40%。在14° C下保持4周后重新适应23° C的肥胖小鼠消耗相同量的能量，并且比保持在23° C下的肥胖小鼠的效率高16%;重新适应的瘦小鼠消耗的能量多12%，但比保持在23° C下的瘦小鼠的效率低53%。结果表明，肥胖小鼠在适应轻度寒冷时能够增加产热并显著降低其能量保持效率，但与瘦小鼠不同，它们在重新适应23° C 4周后迅速恢复到高能量保持效率。
Obese (ob ob) and lean mice at 4 weeks of age were housed at 23° C or 14° C for 4 to 8 weeks to examine effects of acclimation to mild cold on energy balance. Energy intake of young lean mice increased by about 50% when housed at 14° C, but energy intake of cold-acclimated obese mice increased by only 8%. Efficiency of energy retention (ratio of energy gain to energy intake) in obese mice declined from 22%±1.2% at 23° C to 10%±1.8% after 4 weeks at 14° C. Lean mice exhibited a less pronounced response to temperature; their efficiency of energy retention declined from 7%±1.3% at 23° C to 4%±2.2% after 4 weeks at 14° C. After 8 weeks of cold exposure, body weights and efficiency of energy retention became equal in obese and lean mice. Calculated heat production of cold-acclimated obese and lean mice was 40% cigher than that of respective controls. Obese mice reacclimated to 23° C after being kept for 4 weeks at 14° C consumed the same amount of energy and were 16% more efficient than obese maintained at 23° C; reacclimated lean mice consumed 12% more energy but were 53% less efficient than lean mice maintained at 23° C. The results indicate that obese mice are able to increase heat production and markedly reduce their efficiency of energy retention when acclimated to mild cold but that they, unlike lean mice, rapidly revert to a high efficiency of energy retention after 4 weeks of reacclimation to 23° C.
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年轻肥胖 (ob/ob) 小鼠的食物摄入量、体重增加和身体成分。
DOI：
--
发表时间：
1977
期刊：
Journal of NutriLife
影响因子：
--
作者：
Pi;D. Romsos;Gilbert A. Leveille
通讯作者：
Gilbert A. Leveille
过度喂养对肥胖 (ob/ob) 小鼠能量平衡和棕色脂肪产热的影响
影响因子：
64.8
作者：
P. Trayhurn;P. M. Jones;M. McGuckin;A. Goodbody
通讯作者：
A. Goodbody
饲养在 33 度并喂食高碳水化合物或高脂肪饮食的年轻肥胖 (ob/ob) 和瘦小鼠的维持能量需求和能量保留。
DOI：
--
发表时间：
1980
期刊：
Journal of NutriLife
影响因子：
--
作者：
J. Tuig;D. Romsos;G. Leveille
通讯作者：
G. Leveille
影响因子：
2.1
作者：
ROTHWELL, NJ;STOCK, MJ
通讯作者：
STOCK, MJ
肥胖（ob/ob）小鼠的异常棕色脂肪组织：对寒冷适应的反应。
DOI：
10.1152/ajpendo.1980.239.4.e301
发表时间：
1980
期刊：
The American journal of physiology
影响因子：
--
作者：
S. Hogan;J. Himms‐Hagen
通讯作者：
J. Himms‐Hagen