Comparative liver transcriptome analysis in ducklings infected with duck hepatitis A virus 3 (DHAV-3) at 12 and 48 hours post-infection through RNA-seq.
Comparative liver transcriptome analysis in ducklings infected with duck hepatitis A virus 3 (DHAV-3) at 12 and 48 hours post-infection through RNA-seq.
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DOI：
10.1186/s13567-018-0545-7
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发表时间：
2018-06-20
影响因子：
4.4
通讯作者：
Ma B
中科院分区：
文献类型：
--
作者：
Zhang X;Cao C;Liu Y;Qi H;Zhang W;Hao C;Chen H;Zhang Q;Zhang W;Gao M;Wang J;Ma B
鸭甲型肝炎病毒3 （DHAV-3）是小核糖核酸病毒科新型鸟肝病毒属的唯一成员，可给中国养鸭场造成重大经济损失。关于致死性DHAV-3毒株在雏鸭中的致病性和抗病毒分子机制的报道并不充分，而且仍然知之甚少。我们对感染致死性DHAV-3的鸭肝组织进行了全球基因表达谱分析，并筛选了差异表达基因（DEG）。感染后12小时（hpi）和48小时（hpi）分别为1643℃和8979℃。DEG基因通路分析主要涉及代谢途径、宿主免疫反应和病毒入侵等生物学过程。这一结果可能为我们探索DHAV-3毒株的致病性和提高我们对宿主-病毒相互作用的认识提供有价值的信息。本文的在线版本（10.1186/s13567-018-0545-7）包含补充材料，授权用户可使用。
Duck hepatitis A virus 3 (DHAV-3), the only member of the novel genus Avihepatovirus, in the family Picornaviridae, can cause significant economic losses for duck farms in China. Reports on the pathogenicity and the antiviral molecular mechanisms of the lethal DHAV-3 strain in ducklings are inadequate and remain poorly understood. We conducted global gene expression profiling and screened differentially expressed genes (DEG) of duckling liver tissues infected with lethal DHAV-3. There were 1643 DEG and 8979 DEG when compared with mock ducklings at 12 hours post-infection (hpi) and at 48 hpi, respectively. Gene pathway analysis of DEG highlighted mainly biological processes involved in metabolic pathways, host immune responses, and viral invasion. The results may provide valuable information for us to explore the pathogenicity of the virulent DHAV-3 strain and to improve our understanding of host–virus interactions. The online version of this article (10.1186/s13567-018-0545-7) contains supplementary material, which is available to authorized users.
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8.8
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