The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients.
The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients.
复制标题
中国成人滤泡性细支气管炎的临床特征和转归
DOI：
10.1038/s41598-018-25670-8
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发表时间：
2018-05-08
影响因子：
4.6
通讯作者：
Cao M
中科院分区：
文献类型：
--
作者：
Lu J;Ma M;Zhao Q;Meng F;Wang D;Cai H;Cao M
滤泡性细支气管炎（FB）是一种罕见的间质性肺病（ILD），已在不同的临床背景下报告。回顾了2009年至2017年间来自中国南京鼓楼医院的6例经手术肺活检（SLB）证实的FB患者。受试者的平均年龄为42岁（范围：31-55岁）。临床症状轻。实验室检查结果显示红细胞沉降率（ESR）和血清球蛋白升高和贫血。4例肺功能检查正常。5例有基础疾病，如舍格伦综合征、多中心Castleman病、伴自身免疫性肺炎和脓肿。5例胸部影像学表现为间质性肺病（ILD），表现为小叶中心或细支气管周围结节、磨玻璃影、小叶间隔增厚、囊肿和支气管扩张。1例患者出现孤立性肿块。组织病理学检查均显示FB改变。在4例病例中使用泼尼松和/或环磷酰胺，1例进行手术，另1例进行临床监测。随访结束时均存活。FB的成年患者通常症状轻微，有ILD和基础疾病。明确诊断需要SLB。预后取决于他们的基础条件。
Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31–55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases. Five cases had underlying diseases, such as, Sjo¨gren’s syndrome, multi-centric castlemans’ disease, idiopathic pneumonia with autoimmune features and abscess. Five cases presented as interstitial lung disease (ILD) on chest imaging with centrilobular or peribronchiolar nodules, ground glass opacities, interlobular septal thickening, cysts and bronchiectasis. Isolated mass was in one patient. The histopathology suggested the changes of FB in all subjects. Prednisone and/or cyclophosphamide were used in four cases, one did the surgery and the other was clinically monitored. All cases were alive at the end of follow up. The adult patients of FB usually have mild symptoms, ILD and underlying diseases. The definite diagnosis needs SLB. The prognosis is depended on their underlying conditions.
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影响因子：
0.9
作者：
Ikeri NZ;Umerah GO;Ugwu CE;Olusoji O;Adeyomoye A;Ekure E;Daramola AO
通讯作者：
Daramola AO
影响因子：
3.6
作者：
Benesch, M;Kurz, H;Zach, MS
通讯作者：
Zach, MS
DOI：
10.4049/jimmunol.1301576
发表时间：
2013-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Schmitt EG;Haribhai D;Jeschke JC;Co DO;Ziegelbauer J;Yan K;Iwakura Y;Mishra MK;Simpson P;Salzman NH;Williams CB
通讯作者：
Williams CB
影响因子：
1.2
作者：
Iyonaga, K;Ichikado, K;Suga, M
通讯作者：
Suga, M
影响因子：
6.9
作者：
Kobayashi, Hideo;Kanoh, Soichiro;Aida, Shinsuke
通讯作者：
Aida, Shinsuke