Clinical Relevance of Mesenchymal- and Stem-Associated Phenotypes in Circulating Tumor Cells Isolated from Lung Cancer Patients.
Clinical Relevance of Mesenchymal- and Stem-Associated Phenotypes in Circulating Tumor Cells Isolated from Lung Cancer Patients.
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DOI：
10.3390/cancers13092158
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发表时间：
2021-04-29
期刊：
影响因子：
5.2
通讯作者：
Kallergi G
中科院分区：
文献类型：
--
作者：
Pantazaka E;Vardas V;Roumeliotou A;Kakavogiannis S;Kallergi G
肺癌是世界上最常见的恶性肿瘤。大多数肺癌患者在晚期被诊断出来。更糟糕的是，患者的生存率很低。循环肿瘤细胞（CTC）虽然罕见，但已被描述为肺癌进展中的重要参与者。作为一名反恐委员会成员，这绝对不是一件容易的事。首先，它们从原发肿瘤中逃脱，然后它们在血液中移动，必须在非常恶劣的条件下生存，最后，它们形成转移。有人建议采用上皮细胞向间充质细胞转化以及癌症干细胞特征，以使CTCs存活和转移。本文将重点介绍这些特征如何用于估计肺癌患者的预后。肺癌是全球癌症相关死亡率的主要原因。在肺癌的类型中，非小细胞肺癌（NSCLC）更常见，而小细胞肺癌（SCLC）较不常见但更具侵袭性。循环肿瘤细胞（CTC）虽然罕见，但已被描述为肺癌进展中的重要参与者。CTC被认为采用上皮-间充质转化（EMT）表型和癌症干细胞（CSC）的特征。这种EMT（或部分）表型使这些细胞能够从原发性肿瘤中逃脱，进入血液，并在极其不利的条件下生存，然后再定殖到远处的病灶。CSC特征的获得，如自我更新、分化和迁移潜力，进一步反映了CTC的侵袭潜力。CSC已经在肺癌中被鉴定，并且EMT标志物的表达先前与不良临床结果相关。到目前为止，绝大多数研究都集中在CTC检测和计数作为患者生存或监测治疗疗效的预后工具。在这篇综述中，我们强调了CTC中的EMT和CSC标志物，并关注这些表型在非小细胞和小细胞肺癌进展中的临床意义。
Lung cancer is the most frequent malignancy in the world. Most lung cancer patients are diagnosed at an advanced stage. To make matters worse, the survival of patients is very poor. Circulating tumor cells (CTCs), albeit rare, have been portrayed as essential players in the progression of lung cancer. It is definitely not easy being a CTC. First, they escape from the primary tumor, then they travel in the bloodstream, have to survive really harsh conditions, and finally, they form metastases. The adoption of epithelial-to-mesenchymal transition as well as cancer stem cell features has been suggested to allow CTCs to survive and metastasize. This review will focus on how these features can be used to estimate the prognosis of lung cancer patients. Lung cancer is the leading cause of cancer-related mortality globally. Among the types of lung cancer, non-small-cell lung cancer (NSCLC) is more common, while small-cell lung cancer (SCLC) is less frequent yet more aggressive. Circulating tumor cells (CTCs), albeit rare, have been portrayed as essential players in the progression of lung cancer. CTCs are considered to adopt an epithelial-to-mesenchymal transition (EMT) phenotype and characteristics of cancer stem cells (CSCs). This EMT (or partial) phenotype affords these cells the ability to escape from the primary tumor, travel into the bloodstream, and survive extremely adverse conditions, before colonizing distant foci. Acquisition of CSC features, such as self-renewal, differentiation, and migratory potential, further reflect CTCs’ invasive potential. CSCs have been identified in lung cancer, and expression of EMT markers has previously been correlated with poor clinical outcomes. Thus far, a vast majority of studies have concentrated on CTC detection and enumeration as a prognostic tools of patients’ survival or for monitoring treatment efficacy. In this review, we highlight EMT and CSC markers in CTCs and focus on the clinical significance of these phenotypes in the progression of both non-small- and small-cell lung cancer.
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影响因子：
5.2
作者：
de Miguel-Perez, Diego;Isabel Bayarri-Lara, Clara;Jose Serrano, Maria
通讯作者：
Jose Serrano, Maria
影响因子：
28.2
作者：
Drapkin BJ;George J;Christensen CL;Mino-Kenudson M;Dries R;Sundaresan T;Phat S;Myers DT;Zhong J;Igo P;Hazar-Rethinam MH;Licausi JA;Gomez-Caraballo M;Kem M;Jani KN;Azimi R;Abedpour N;Menon R;Lakis S;Heist RS;Büttner R;Haas S;Sequist LV;Shaw AT;Wong KK;Hata AN;Toner M;Maheswaran S;Haber DA;Peifer M;Dyson N;Thomas RK;Farago AF
通讯作者：
Farago AF
影响因子：
20.4
作者：
Coghlin, Caroline L.;Smith, Louise J.;Kerr, Keith M.
通讯作者：
Kerr, Keith M.
影响因子：
6
作者：
Hou, Jian-Mei;Krebs, Matthew;Dive, Caroline
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Dive, Caroline
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影响因子：
3.1
作者：
Jiang, Sha-Sha;Deng, Bo;Wang, Ru-Wen
通讯作者：
Wang, Ru-Wen