Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males.
Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males.
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DOI：
10.1038/srep05663
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发表时间：
2014-07-11
影响因子：
4.6
通讯作者：
Higaki J
中科院分区：
文献类型：
--
作者：
Okura T;Miyoshi K;Irita J;Enomoto D;Nagao T;Kukida M;Tanino A;Kudo K;Pei Z;Higaki J
据报道，高同型血与心血管疾病，特别是中风有关。颈动脉超声测量的阻力指数（RI）是评估脑梗死风险的一个既定变量。本研究的目的是评估同型半胱氨酸浓度与颈动脉RI之间的关系，颈动脉RI是原发性高血压患者脑血管阻力的标志。我们测量了261例患者的血清总同型半胱氨酸和颈动脉RI。采用多元线性回归分析确定同型半胱氨酸与颈动脉RI和内膜中膜厚度（IMT）的关系。年龄、性别、BMI、收缩压（SBP）、同型半胱氨酸、总胆固醇、高密度脂蛋白-胆固醇（HDL-C）、尿酸、CRP、HbA1c、估计肾小球滤过率和使用降压药作为独立变量。年龄、性别、抗高血压药物的使用、HDL-C和同型半胱氨酸水平被证明是颈动脉RI的重要预测因素，但不是IMT。65岁以上男性的多元回归分析显示，同型半胱氨酸和收缩压与颈动脉RI显著相关。在老年男性患者中，在多变量模型中，同型半胱氨酸是颈动脉RI的最强预测因子（B = 0.0068, CI = 0.0017-0.0120, P = 0.011）。总之，高同型半胱氨酸血症与颈动脉RI相关，颈动脉RI是脑血管阻力的替代标志物，尤其是在老年男性中。
Hyperhomocystemia has been reported to be associated with cardiovascular disease, especially stroke. The resistive index (RI) estimated by carotid ultrasound is an established variable for estimating the risk of cerebral infarction. The aim of this study was to evaluate the relationship between homocysteine concentration and carotid RI, a marker of cerebral vascular resistance in essential hypertensive patients. We measured serum total homocysteine and carotid RI in 261 patients. Multiple linear regression analysis was used to determine the association of homocysteine with carotid RI and intima media thickness (IMT). Age, sex, BMI, systolic blood pressure (SBP), homocysteine, total cholesterol, high density lipoprotein-cholesterol (HDL-C), uric acid, CRP, HbA1c, estimated glomerular filtration rate, and use of antihypertensive agents were included as independent variables. Age, sex, use of antihypertensive agents, HDL-C and homocysteine levels were shown to be significant predictors of carotid RI, but not IMT. Multiple regression analysis in men older than 65 years showed homocysteine and SBP were associated significantly with carotid RI. In elderly male patients, homocysteine was the strongest predictor of carotid RI (B = 0.0068, CI = 0.0017–0.0120, P = 0.011) in the multivariate model. In conclusion, hyperhomocysteinemia is associated with carotid RI, a surrogate marker of cerebral vascular resistance, especially in elderly men.
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影响因子：
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作者：
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