Theory of sleep/wake cycles affecting brain elastography.
Theory of sleep/wake cycles affecting brain elastography.
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DOI：
10.1088/1361-6560/ac9e40
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发表时间：
2022-11-16
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
随着脑弹性成像在临床上的应用越来越多，关于脑在体内的基线粘弹性的基本问题仍然存在。此外，弹性成像测量如何以及为什么会随时间变化的潜在机制仍然没有很好地理解。为了研究这些问题，使用光学相干断层扫描仪的反射剪切波弹性成像在小鼠模型上实现，无论是在清醒状态下还是在睡眠状态下，其中在大脑中的胶质淋巴液流动系统中存在已知的变化。我们发现，剪切波速度，刚度的措施，约12%的变化之间的两个状态，睡眠与清醒，在整个大脑皮层成像体积。我们的双相（流体加固体）组织的微通道流动模型提供了一个合理的流变学模型的基础上的分形分支血管和血管周围系统，加上第二个平行系统代表更精细的规模glymphatic流体微通道。通过调整胶质淋巴系统流体体积与已知的清醒/睡眠变化成比例，我们能够近似预测测量的剪切波速度及其随胶质淋巴系统状态的变化。这个模型的优点是，它的主要参数是来自解剖措施，并与其他主要的衍生分支流体结构，包括默里定律。对临床研究的影响是，大脑的弹性成像受到血管、血管周围和胶质淋巴系统的调节或失调的强烈影响。
As elastography of the brain finds increasing clinical applications, fundamental questions remain about baseline viscoelastic properties of the brain in vivo. Furthermore, the underlying mechanisms of how and why elastographic measures can change over time are still not well understood. To study these issues, reverberant shear wave elastography using an optical coherence tomography scanner is implemented on a mouse model, both under awake conditions and in a sleep state where there are known changes in the glymphatic fluid flow system in the brain. We find that shear wave speed, a measure of stiffness, changes by approximately 12% between the two states, sleep vs awake, in the entire cortical brain imaging volume. Our microchannel flow model of biphasic (fluid plus solid) tissue provides a plausible rheological model based on the fractal branching vascular and perivascular system, plus a second parallel system representing the finer scale glymphatic fluid microchannels. By adjusting the glymphatic system fluid volume proportional to the known wake/sleep changes, we are able to approximately predict the measured shear wave speeds and their change with the state of the glymphatic system. The advantages of this model are that its main parameters are derived from anatomical measures and are linked to other major derivations of branching fluid structures including Murray’s Law. The implications for clinical studies are that elastography of the brain is strongly influenced by the regulation or dysregulation of the vascular, perivascular, and glymphatic systems.
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影响因子：
5.7
作者：
Murphy MC;Huston J 3rd;Ehman RL
通讯作者：
Ehman RL
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
通讯作者：
Starr JM
DOI：
10.1073/pnas.94.26.14826
发表时间：
1997-12-23
影响因子：
11.1
作者：
Malonek, D;Dirnagl, U;Grinvald, A
通讯作者：
Grinvald, A
DOI：
10.1152/ajpheart.00579.2005
发表时间：
2006-02-01
影响因子：
4.8
作者：
Kassab, GS
通讯作者：
Kassab, GS
DOI：
10.1259/bjr.20200265
发表时间：
2021-03-01
期刊：
The British journal of radiology
影响因子：
--
作者：
Arani A;Manduca A;Ehman RL;Huston Iii J
通讯作者：
Huston Iii J