Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States.
Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States.
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DOI：
10.1007/s10654-016-0169-z
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发表时间：
2016-09
影响因子：
13.6
通讯作者：
CHANCES consortium
中科院分区：
文献类型：
--
作者：
Arnold M;Freisling H;Stolzenberg-Solomon R;Kee F;O'Doherty MG;Ordóñez-Mena JM;Wilsgaard T;May AM;Bueno-de-Mesquita HB;Tjønneland A;Orfanos P;Trichopoulou A;Boffetta P;Bray F;Jenab M;Soerjomataram I;CHANCES consortium
最近的研究表明，与超重和肥胖有关的癌症风险是由时间介导的，并且可能通过使用超重的生命年来更好地近似。在这项研究中，我们的目的是评估老年人超重持续时间和强度对患不同形式癌症风险的影响。纳入了来自7项欧洲队列研究和1项美国队列研究的研究参与者，这些研究参与者在随访期间进行了两次或多次体重评估（n= 329，576）。使用二次增长模型估计各年龄段的体重指数（BMI）轨迹;计算超重持续时间（BMI≥25）和累积加权超重年数。在多变量考克斯模型和随机效应分析中，超重持续时间较长与肥胖相关癌症的发病率显著相关（每10年增量的总体风险比（HR）：1.36; 95%CI：1.12-1.60），但也增加了绝经后乳腺癌和结直肠癌的风险。此外，考虑到超重的程度，进一步增加了患肥胖相关癌症的风险。与超重持续时间较长相关的风险在男性中高于女性，并通过吸烟减弱。对于绝经后乳腺癌，风险增加仅限于从未使用激素治疗的女性。总体而言，所有与肥胖相关的癌症中有8.4%可归因于任何年龄的超重。这些发现为超重持续时间在癌症病因学中的作用提供了进一步的见解，并表明体重控制在所有年龄段都是相关的。这些知识对于制定有效和有针对性的癌症预防策略至关重要。
Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n=329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI≥25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obesity-related cancer (overall Hazard Ratio (HR) per 10-yr increment: 1.36; 95%CI: 1.12-1.60), but also increased the risk of postmenopausal breast and colorectal cancer. Additionally accounting for the degree of overweight further increased the risk of obesity-related cancer. Risks associated with a longer overweight duration were higher in men than in women and were attenuated by smoking. For postmenopausal breast cancer, increased risks were confined to women who never used hormone therapy. Overall, 8.4% of all obesity-related cancers could be attributed to overweight at any age. These findings provide further insights into the role of overweight duration in the etiology of cancer and indicate that weight control is relevant at all ages. This knowledge is vital for the development of effective and targeted cancer prevention strategies.
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影响因子：
2
作者：
Heo, M;Faith, MS;Allison, DB
通讯作者：
Allison, DB
影响因子：
5
作者：
MIETTINE.OS
通讯作者：
MIETTINE.OS
影响因子：
5.4
作者：
Henley, SJ;Flanders, WD;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
1.9
作者：
GREENLAND, S;DRESCHER, K
通讯作者：
DRESCHER, K
DOI：
10.1016/s0140-6736(10)62037-5
发表时间：
2011-02-12
期刊：
Lancet (London, England)
影响因子：
--
作者：
Finucane MM;Stevens GA;Cowan MJ;Danaei G;Lin JK;Paciorek CJ;Singh GM;Gutierrez HR;Lu Y;Bahalim AN;Farzadfar F;Riley LM;Ezzati M;Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
通讯作者：
Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)