Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats.
Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats.
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DOI：
10.1155/2018/2967127
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发表时间：
2018
影响因子：
4.3
通讯作者：
Yorek MA
中科院分区：
文献类型：
--
作者：
Davidson EP;Coppey LJ;Shevalye H;Obrosov A;Yorek MA
In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model. Four weeks after the onset of hyperglycemia, diabetic rats were treated via the diet with 3 different amounts of menhaden oil with or without salsalate for 12 weeks. Afterwards, vascular reactivity of epineurial arterioles and neuropathy-related endpoints were examined. The addition of salsalate to high-fat diets enriched with 10% or 25% kcal of menhaden oil protected vascular reactivity to acetylcholine and calcium gene-related peptide, motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, and cornea sensitivity to a greater extent than 10% or 25% menhaden oil alone. Vascular and neural function was maximally protected with diet containing 45% kcal as menhaden oil, and adding salsalate did not provide any additional benefit. Salsalate alone in the high-fat diet of diabetic rats provided minimal protection/improvement of vascular and neural dysfunction. These studies imply that dietary salsalate in combination with lower amounts of menhaden oil can provide greater benefit toward diabetes-induced vascular and neural impairment than menhaden oil alone.
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影响因子：
62.1
作者：
Serhan, Charles N.;Petasis, Nicos A.
通讯作者：
Petasis, Nicos A.
影响因子：
39.2
作者：
Goldfine AB;Fonseca V;Jablonski KA;Chen YD;Tipton L;Staten MA;Shoelson SE;Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
通讯作者：
Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
影响因子：
2.5
作者：
Coppey, Lawrence J.;Davidson, Eric P.;Yorek, Mark A.
通讯作者：
Yorek, Mark A.
影响因子：
2.5
作者：
Shevalye, Hanna;Yorek, Matthew S.;Yorek, Mark A.
通讯作者：
Yorek, Mark A.
影响因子：
4.4
作者：
Cortina, Maria Soledad;He, Jiucheng;Bazan, Haydee E. P.
通讯作者：
Bazan, Haydee E. P.