Resolvins and protectins in inflammation resolution.
Resolvins and protectins in inflammation resolution.
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DOI：
10.1021/cr100396c
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发表时间：
2011-10-12
期刊：
影响因子：
62.1
通讯作者：
Petasis, Nicos A.
中科院分区：
文献类型：
--
作者：
Serhan, Charles N.;Petasis, Nicos A.
炎症过程在健康和疾病中的关键作用早已被认识到，1但调节炎症进展和消退的详细分子机制和生物学事件仍然令人感兴趣。最近的一些研究提供了强有力的证据，表明炎症的消退不是一个被动的过程，正如以前所认为的那样。相反，消退是一个生物合成活性过程，由生化介质和受体信号通路调节，并由专门的促消退介质（SPM）驱动。特别是，在Serhan及其团队的一些发现之后，作者及其合作者介绍并系统地研究了一些来自多不饱和脂肪酸（PUFA）的SPM，包括脂氧素，E系列resolvins，D系列resolvins，protectins/neuroprotectins，以及最近的maresins。本文综述了resolvins和protectins的研究进展，重点介绍了resolvins和protectins的生物化学途径。还提供了涵盖这些抗炎和促消退脂质介质的不同方面的其他综述，5包括免疫学，6，7病理学，8生物化学，9药理学10和化学，11。6月9日，12日
The critical role of inflammatory processes in health and disease has long been recognized, 1 yet the detailed molecular mechanisms and biological events that regulate the progression and resolution of inflammation remain of interest. A number of recent investigations have provided strong evidence that the resolution of inflammation is not a passive process, as believed earlier. 2À4 Instead, resolution is a biosynthetically active process, regulated by biochemical mediators and receptor-signaling pathways and driven by specialized pro-resolving mediators (SPM). In particular, following a number of findings by Serhan and his group, the authors and their collaborators introduced and systematically investigated a number of SPM derived from poly-unsaturated fatty acids (PUFA), including lipoxins, E-series resolvins, D-series resolvins, protectins/neuroprotectins, and, most recently, maresins. This review summarizes efforts on the resolvins and protectins with an emphasis on the corresponding biochemical pathways. Additional reviews covering different aspects of these anti-inflammatory and pro-resolving lipid mediators, 5 including immunology, 6, 7 pathology, 8 biochemistry, 9 pharmacology10 and chemistry, 11 are also available. 6À9, 12
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DOI：
10.1016/j.bbalip.2010.08.002
发表时间：
2010-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bannenberg G;Serhan CN
通讯作者：
Serhan CN
影响因子：
7.1
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
DOI：
10.1016/0006-291x(84)90601-6
发表时间：
1984-01-01
影响因子：
3.1
作者：
BAZAN, NG;BIRKLE, DL;REDDY, TS
通讯作者：
REDDY, TS
影响因子：
11.5
作者：
Cleland, LG;James, MJ;Proudman, SM
通讯作者：
Proudman, SM
影响因子：
4.4
作者：
Arita, Makoto;Ohira, Taisuke;Serhan, Charles N.
通讯作者：
Serhan, Charles N.