Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects.
Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects.
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DOI：
10.3390/life12122023
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发表时间：
2022-12-04
期刊：
影响因子：
3.2
通讯作者：
Heiss, Christian
中科院分区：
文献类型：
--
作者：
Bapir, Mariam;Untracht, Gavrielle R. R.;Hunt, Julie E. A.;McVey, John H. H.;Harris, Jenny;Skene, Simon S. S.;Campagnolo, Paola;Dikaios, Nikolaos;Rodriguez-Mateos, Ana;Sampson, David D. D.;Sampson, Danuta M. M.;Heiss, Christian
股动脉（FA）内皮功能是下肢血管健康的一个有前途的生物标志物，用于外周动脉疾病（PAD）的预防和治疗;然而，年龄对FA内皮功能的影响尚未在健康成人中报道。因此，我们评价了FA和肱动脉（BA）（n = 20）中流量介导的扩张（FMD）的可重复性和可接受性，并在年龄22-76岁的健康非吸烟者（n = 50）中进行了FA和BA-FMD横截面测量。FMD方案表现出类似的良好再现性。腿部闭塞被认为比手臂闭塞更不舒服;大腿闭塞比前臂和小腿闭塞更不耐受。小腿闭塞的FA-FMD低于BA-FMD（6.0 ± 1.1% vs 6.4 ± 1.3%，p = 0.030）。多变量线性回归分析表明，年龄（-0.4%/十年）是FA-FMD的重要独立预测因素（R2 = 0.35，p = 0.002）。FMD的年龄依赖性下降在FA和BA之间没有显著差异（p相互作用年龄位置= 0.388）。在老年参与者中，40%的基线FA壁剪切应力（WSS）值<5 dyne/cm 2，这被认为是促动脉粥样硬化的。总之，在健康成人中，FA和BA的内皮功能随着年龄的增长而下降。年龄依赖性FA增大导致WSS显著降低，这可能部分解释了PAD的年龄依赖性易感性。
Femoral artery (FA) endothelial function is a promising biomarker of lower extremity vascular health for peripheral artery disease (PAD) prevention and treatment; however, the impact of age on FA endothelial function has not been reported in healthy adults. Therefore, we evaluated the reproducibility and acceptability of flow-mediated dilation (FMD) in the FA and brachial artery (BA) (n = 20) and performed cross-sectional FA- and BA-FMD measurements in healthy non-smokers aged 22–76 years (n = 50). FMD protocols demonstrated similar good reproducibility. Leg occlusion was deemed more uncomfortable than arm occlusion; thigh occlusion was less tolerated than forearm and calf occlusion. FA-FMD with calf occlusion was lower than BA-FMD (6.0 ± 1.1% vs 6.4 ± 1.3%, p = 0.030). Multivariate linear regression analysis indicated that age (−0.4%/decade) was a significant independent predictor of FA-FMD (R2 = 0.35, p = 0.002). The age-dependent decline in FMD did not significantly differ between FA and BA (pinteraction agexlocation = 0.388). In older participants, 40% of baseline FA wall shear stress (WSS) values were <5 dyne/cm2, which is regarded as pro-atherogenic. In conclusion, endothelial function declines similarly with age in the FA and the BA in healthy adults. The age-dependent FA enlargement results in a critical decrease in WSS that may explain part of the age-dependent predisposition for PAD.
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影响因子：
2.5
作者：
Roberts KA;Draijer R;Hopkins ND;de Graaf Y;Holder SM;Carter SE;Thijssen DHJ;Low DA
通讯作者：
Low DA
外周动脉弹性的变化是通过体积 - 尺度计量法对充血反应的反应，作为流动介导的血管舒张的可能评估。
影响因子：
4.6
作者：
通讯作者：
--
影响因子：
24
作者：
Heiss, C;Keymel, S;Kalka, C
通讯作者：
Kalka, C
影响因子：
8.3
作者：
Domagala, Teresa B.;Szeffler, Agata;Kalinowski, Leszek
通讯作者：
Kalinowski, Leszek
影响因子：
5
作者：
Bapir, Mariam;Campagnolo, Paola;Rodriguez-Mateos, Ana;Skene, Simon S.;Heiss, Christian
通讯作者：
Heiss, Christian