Human Physiological Responses to a Single Deep Helium-Oxygen Diving.
Human Physiological Responses to a Single Deep Helium-Oxygen Diving.
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DOI：
10.3389/fphys.2021.735986
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发表时间：
2021
影响因子：
4
通讯作者：
Wu JG
中科院分区：
文献类型：
--
作者：
Bao XC;Shen Q;Fang YQ;Wu JG
目的：探讨单次氦-氧深潜对人体生理机能的影响。方法：40名男性潜水员在开放水域进行氦氧潜水至80米深的海水(MSW)。总潜水时间为280min，吸氦氧时间为20min。在潜水前后，采集血液和唾液样本，并检测血细胞计数、心脏损伤、氧化应激、血管内皮细胞激活和激素生物标志物。结果：80MSW氦氧潜水后，小鼠外周血中粒细胞百分比(GR%)显著升高，淋巴细胞百分比(LYM%)、中间细胞百分比(MID%)、红细胞计数(RBC)、红细胞压积(Hct)和血小板计数(PLT)均显著下降。在潜水过程中，血清中肌酸激酶(CK)和淀粉酶α1(AMY1)的浓度以及唾液中的睾酮水平升高，而唾液中的IgA水平则相反。潜水使血清谷胱甘肽(GSH)水平显着升高，血管细胞黏附分子-1(VCAM-1)水平降低，但对丙二醛(MDA)和内皮素-1(ET-1)水平无明显影响。结论：单次80MSW氦氧潜水激活血管内皮细胞，导致骨骼肌损伤，并诱导氧化应激和生理应激反应，这反映在生物标记物浓度的变化上。
Objective: The objective of this study was to explore whether a single deep helium-oxygen (heliox) dive affects physiological function. Methods: A total of 40 male divers performed an open-water heliox dive to 80 m of seawater (msw). The total diving time was 280 min, and the breathing helium-oxygen time was 20 min. Before and after the dive, blood and saliva samples were collected, and blood cell counts, cardiac damage, oxidative stress, vascular endothelial activation, and hormonal biomarkers were assayed. Results: An 80 msw heliox dive induced a significant increase in the percentage of granulocytes (GR %), whereas the percentage of lymphocytes (LYM %), percentage of intermediate cells (MID %), red blood cell number (RBC), hematocrit (hCT), and platelets (PLT) decreased. During the dive, concentrations of creatine kinase (CK), a myocardial-specific isoenzyme of creatine kinase (CK-MB) in serum and amylase alpha 1 (AMY1), and testosterone levels in saliva increased, in contrast, IgA levels in saliva decreased. Diving caused a significant increase in serum glutathione (GSH) levels and reduced vascular cell adhesion molecule-1 (VCAM-1) levels but had no effect on malondialdehyde (MDA) and endothelin-1 (ET-1) levels. Conclusion: A single 80 msw heliox dive activates the endothelium, causes skeletal-muscle damage, and induces oxidative stress and physiological stress responses, as reflected in changes in biomarker concentrations.
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影响因子：
4
作者：
Lambrechts K;de Maistre S;Abraini JH;Blatteau JE;Risso JJ;Vallée N
通讯作者：
Vallée N
影响因子：
5.8
作者：
Pendergast, David R.;Moon, Richard E.;Zamparo, Paola
通讯作者：
Zamparo, Paola
DOI：
10.1249/mss.0b013e3181aa04cc
发表时间：
2009-12-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Marinovic, Jasna;Ljubkovic, Marko;Dujic, Zeljko
通讯作者：
Dujic, Zeljko
影响因子：
3.3
作者：
Ferrer, M. D.;Sureda, A.;Pons, A.
通讯作者：
Pons, A.
影响因子：
2.5
作者：
Marlinge, Marion;Coulange, Mathieu;Joulia, Fabrice C.
通讯作者：
Joulia, Fabrice C.