A clinical overview of pheochromocytomas/paragangliomas and carcinoid tumors.
A clinical overview of pheochromocytomas/paragangliomas and carcinoid tumors.
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DOI：
10.1016/j.nucmedbio.2008.04.007
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发表时间：
2008-08
影响因子：
3.1
通讯作者：
Pacak, Karel
中科院分区：
文献类型：
--
作者：
Ilias, Ioannis;Pacak, Karel
嗜铬细胞瘤/副神经节瘤是罕见的肿瘤，大多数是散发性的。通过测量血浆变肾上腺素可以更好地提供疾病的生化证据，并且比尿液中的测定更简单;其实施正在扩大。计算机断层扫描或磁共振成像的解剖成像后应进行功能（核医学）成像：嗜铬细胞瘤特异性方法是首选。治疗方法是手术;对于不可手术的疾病，还有其他选择。5年生存率为50%。类癌瘤来源于前肠、中肠或后肠中产生嗜铬细胞的嗜铬细胞。生化筛查（和随访）通过测量尿液中的5-羟基吲哚乙酸来进行。对于大多数类癌，功能成像在定位原发性肿瘤方面优于其他方式。手术是治疗的首选;不可切除的肿瘤用生长抑素类似物或化疗治疗。类癌患者的总体5年生存率为67%。
Pheochromocytomas/paragangliomas are rare tumors, most are sporadic. Biochemical proof of disease is better with measurement of plasma metanephrines and less cumbersome than determinations in urine; its implementation is expanding. Anatomical imaging with computed tomography or magnetic resonance imaging should be followed by functional (nuclear medicine) imaging: chromaffin-tumor-specific methods are preferred. Treatment is surgical; for non-operable disease other options are available. Overall 5-year survival is 50%. Carcinoid tumors derive from serotonin-producing enterochromaffin cells in the fore-, mid- or hindgut. Biochemical screening (and follow-up) is done with measurements of 5-hydroxyindoloacetic acid in urine. For most carcinoids functional imaging is better than other modalities in localizing primary tumors. Surgery is the treatment of choice; non-resectable tumors are treated with somatostatin analogs or chemotherapy. Overall 5-year survival for patients with carcinoids is 67%.
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影响因子：
19.7
作者：
Hoegerle, S;Nitzsche, E;Neumann, HPH
通讯作者：
Neumann, HPH
影响因子：
5.8
作者：
Ilias, I;Yu, J;Pacak, K
通讯作者：
Pacak, K
影响因子：
5.8
作者：
Ilias, I;Torpy, DJ;Nieman, LK
通讯作者：
Nieman, LK
影响因子：
2.4
作者：
Garrot, Crain;Stuart, Keith
通讯作者：
Stuart, Keith
DOI：
10.1196/annals.1353.029
发表时间：
2006-01-01
期刊：
PHEOCHROMOCYTOMA
影响因子：
--
作者：
Cleary, Susannah;Phillips, Jacqueline K.
通讯作者：
Phillips, Jacqueline K.