Association of callous traits with reduced neural response to others' pain in children with conduct problems.
Association of callous traits with reduced neural response to others' pain in children with conduct problems.
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DOI：
10.1016/j.cub.2013.04.018
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发表时间：
2013-05-20
期刊：
影响因子：
9.2
通讯作者：
Viding, Essi
中科院分区：
文献类型：
--
作者：
Lockwood, Patricia L.;Sebastian, Catherine L.;McCrory, Eamon J.;Hyde, Zoe H.;Gu, Xiaosi;De Brito, Stephane A.;Viding, Essi
有行为问题的儿童持续侵犯他人的权利，并代表了相当大的社会成本。这些孩子对他人的痛苦也表现出非典型的移情反应，这可能是他们暴力和反社会行为的部分原因。冷酷无情的特征表明这些孩子缺乏同情心，并赋予成年精神病的风险。研究对他人疼痛的神经反应是一种生态学上有效的方法来探索移情处理，但对CP儿童的研究还没有定论。我们使用功能性磁共振成像（fMRI），在大样本的CP儿童和匹配的对照组中测量了对他人疼痛（与无疼痛）照片的神经反应。与对照组相比，CP儿童在双侧前额叶（AI）、前扣带皮层（ACC）和额下回（与先前研究中的疼痛共情相关的区域）对他人疼痛的血氧水平依赖性反应降低。在脑瘫组中，冷酷无情的特质与对他人疼痛的反应呈负相关。我们的结论是，脑瘫儿童对他人的疼痛有非典型的神经反应。冷酷无情的特质和AI/ACC反应之间的负相关可能反映了早期的神经生物学标志物索引成人精神病中出现的共情缺陷的风险。行为问题儿童对他人疼痛的神经反应减弱前额叶、前扣带皮层和额下回的减少与减少幅度相关的无情特征研究结果可能反映了成人精神病的早期神经生物学风险
Children with conduct problems (CP) persistently violate others’ rights and represent a considerable societal cost. These children also display atypical empathic responses to others’ distress, which may partly account for their violent and antisocial behavior. Callous traits index lack of empathy in these children and confer risk for adult psychopathy. Investigating neural responses to others’ pain is an ecologically valid method to probe empathic processing, but studies in children with CP have been inconclusive. Using functional magnetic resonance imaging (fMRI), we measured neural responses to pictures of others in pain (versus no pain) in a large sample of children with CP and matched controls. Relative to controls, children with CP showed reduced blood oxygen level-dependent responses to others’ pain in bilateral anterior insula (AI), anterior cingulate cortex (ACC), and inferior frontal gyrus, regions associated with empathy for pain in previous studies. In the CP group, callous traits were negatively associated with responses to others’ pain in AI and ACC. We conclude that children with CP have atypical neural responses to others’ pain. The negative association between callous traits and AI/ACC response could reflect an early neurobiological marker indexing risk for empathic deficits seen in adult psychopathy. Children with conduct problems showed reduced neural responses to others’ pain Reductions in anterior insula, anterior cingulate cortex, and inferior frontal gyrus Callous traits associated with the magnitude of reduction Findings may reflect early neurobiological risk for adult psychopathy
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