Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response.
Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response.
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DOI:
10.1007/s00429-010-0265-x
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发表时间:
2010-06
影响因子:
3.1
通讯作者:
Critchley, Hugo D.
中科院分区:
文献类型:
--
作者:
Medford, Nick;Critchley, Hugo D.
关键词:
There is now a wealth of evidence that anterior insular and anterior cingulate cortices have a close functional relationship, such that they may be considered together as input and output regions of a functional system. This system is typically engaged across cognitive, affective, and behavioural contexts, suggesting that it is of fundamental importance for mental life. Here, we review the literature and reinforce the case that these brain regions are crucial, firstly, for the production of subjective feelings and, secondly, for co-ordinating appropriate responses to internal and external events. This model seeks to integrate higher-order cortical functions with sensory representation and autonomic control: it is argued that feeling states emerge from the raw data of sensory (including interoceptive) inputs and are integrated through representations in conscious awareness. Correspondingly, autonomic nervous system reactivity is particularly important amongst the responses that accompany conscious experiences. Potential clinical implications are also discussed.
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DOI:
10.1152/ajpgi.00461.2006
发表时间:
2007-07-01
影响因子:
4.5
作者:
Coen, Steven J.;Gregory, Lloyd J.;Aziz, Qasim
通讯作者:
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影响因子:
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通讯作者:
Dolan, RJ
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