Clinical outcomes for Day 3 double cleavage-stage embryo transfers versus Day 5 or 6 single blastocyst transfer in frozen-thawed cycles: a retrospective comparative analysis.
Clinical outcomes for Day 3 double cleavage-stage embryo transfers versus Day 5 or 6 single blastocyst transfer in frozen-thawed cycles: a retrospective comparative analysis.
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DOI：
10.1177/03000605211062461
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Jin M
中科院分区：
文献类型：
--
作者：
Rao J;Qiu F;Tian S;Yu Y;Zhang Y;Gu Z;Cai Y;Jin F;Jin M
本研究旨在比较冷冻胚胎移植（FET）周期中第3天（D3）双卵裂期胚胎和第5/6天（D5/6）单囊胚移植的临床结局，以制定更合适的胚胎移植策略。我们回顾性分析了2017年4月至2021年3月期间518名女性的609个FET周期。将所有FET分配至D3-DET组（移植第3天双卵裂期胚胎）、D5-SBT组（移植第5天单囊胚）或D 6-SBT组（移植第6天单囊胚）。比较分析两组的临床疗效。D3-DET组和D5-SBT组的生化妊娠率、临床妊娠率或继续妊娠率无显著差异，但两组的这些比率均显著高于D 6-SBT组。D5-SBT组的种植率显著高于D3-DET组。D5-SBT组和D 6-SBT组的双胎妊娠率显著低于D3-DET组。这项研究表明，D5-SBT是移植的首选。D 6-SBT降低了妊娠率，使其成为移植此类胚胎的更谨慎选择。
This study aimed to compare the clinical outcomes for transfer of Day 3 (D3) double cleavage-stage embryos and Day 5/6 (D5/6) single blastocysts in the frozen embryo transfer (FET) cycle to formulate a more appropriate embryo transplantation strategy. We retrospectively analyzed 609 FET cycles from 518 women from April 2017 to March 2021. All FETs were assigned to the D3-DET group (transfer of a Day 3 double cleavage-stage embryo), D5-SBT group (transfer of a Day 5 single blastocyst), or D6-SBT group (transfer of a Day 6 single blastocyst). Clinical outcomes were comparatively analyzed. There were no significant differences in the biochemical pregnancy rate, clinical pregnancy rate, or ongoing pregnancy rate between the D3-DET and D5-SBT groups, but these rates in the two groups were all significantly higher compared with those in the D6-SBT group. The implantation rate in the D5-SBT group was significantly higher than that in the D3-DET group. The twin pregnancy rate in the D5-SBT and D6-SBT groups was significantly lower than that in the D3-DET group. This study suggests that D5-SBT is the preferred option for transplantation. D6-SBT reduces the pregnancy rate, making it a more cautious choice for transfer of such embryos.
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