Clinico-pathologic features of fatal disease attributed to new variants of endotheliotropic herpesviruses in two Asian elephants (Elephas maximus).
Clinico-pathologic features of fatal disease attributed to new variants of endotheliotropic herpesviruses in two Asian elephants (Elephas maximus).
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DOI：
10.1354/vp.46-1-97
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发表时间：
2009-01
影响因子：
2.4
通讯作者：
Hayward GS
中科院分区：
文献类型：
--
作者：
Garner MM;Helmick K;Ochsenreiter J;Richman LK;Latimer E;Wise AG;Maes RK;Kiupel M;Nordhausen RW;Zong JC;Hayward GS
与严重的大象疾病相关的第一个疱疹病毒被称为嗜内皮疱疹病毒（EEHV），因为它们能够感染毛细血管内皮细胞并导致潜在的致命疾病。两种相关的病毒，EEHV1和EEHV2，已被描述的基础上的遗传组成。本报告描述了2例亚洲象致死性亲内皮细胞疱疹病毒感染的临床病理特征的相似性和差异性，由以前未被识别的病毒在β疱疹病毒亚科，这是显着不同的2个以前研究的致命长鼻病毒，基于聚合酶链反应序列分析的病毒基因组的2个片段。除了先前报告的腹水、广泛内脏水肿、瘀点和毛细血管损伤外，EEHV 3感染的重要额外发现是存在肉眼可见的肾髓质出血、各种组织中的较大静脉和动脉的嗜性、相对高密度的肾疱疹包涵体和视网膜血管受累。这些发现表明选择性器官嗜性较低，这可能赋予EEHV 3更高程度的毒力。
The first herpesviruses described in association with serious elephant disease were referred to as endotheliotropic herpesviruses (EEHV) because of their ability to infect capillary endothelial cells and cause potentially fatal disease. Two related viruses, EEHV1 and EEHV2, have been described based on genetic composition. This report describes the similarities and differences in clinicopathologic features of 2 cases of fatal endotheliotropic herpesvirus infections in Asian elephants caused by a previously unrecognized virus within the betaherpesvirus subfamily that is markedly divergent from the 2 previously studied fatal probosciviruses, based on polymerase chain reaction sequence analysis of 2 segments of the viral genome. In addition to ascites, widespread visceral edema, petechiae, and capillary damage previously reported, important additional findings with EEHV3 infection were the presence of grossly visible renal medullary hemorrhage, a tropism for larger veins and arteries in various tissues, relatively high density of renal herpetic inclusions, and involvement of the retinal vessels. These findings indicate a less selective organ tropism, and this may confer a higher degree of virulence for EEHV3.
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影响因子：
3.3
作者：
Wellehan, James F. X.;Johnson, April J.;Isaza, Ramiro
通讯作者：
Isaza, Ramiro
影响因子：
1.4
作者：
Hargis, AM;Ginn, PE;Garber, RL
通讯作者：
Garber, RL
影响因子：
3.8
作者：
Ehlers, Bernhard;Dural, Guezin;Hentschke, Jochen
通讯作者：
Hentschke, Jochen
影响因子：
1.3
作者：
Richman, LK;Montali, RJ;Hayward, GS
通讯作者：
Hayward, GS
影响因子：
3.3
作者：
Fickel, J;Richman, LK;Pitra, C
通讯作者：
Pitra, C