A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
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我们在中国人中进行了一项与胃癌(GC)和食管鳞癌(ESCC)相关的全基因组研究，对551,152个单核苷酸多态(SNPs)进行了基因分型。我们报告了对来自五项研究的2240例GC、2115例ESCC和3302例对照的综合分析。在调整了年龄、性别和研究的Logistic回归模型中，10q23的多个变异对GC和ESCC具有独立的全基因组意义。在胃癌(P=8.4 0×10−9；每等位基因优势比(OR)=1.3 1)和食管癌(P=3.85×10−9；OR=1.3 4)中有一个显著的信号。与GC的关系因解剖部位不同而异。位于贲门部的肿瘤相关性较强(P=4.19×10−15；OR=1.5 7)，位于非贲门部的肿瘤无相关性(P=0.44；OR=1.0 5)。我们在10q23的发现可以为中国这两种癌症的高发病率提供洞察。
We conducted a genome-wide association study of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 single nucleotide polymorphisms (SNPs). We report a combined analysis of 2,240 GC cases, 2,115 ESCC cases, and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex, and study, multiple variants at 10q23 had genome-wide significance for GC and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for GC (P=8.40×10−9; per allele odds ratio (OR) = 1.31) and ESCC (P=3.85×10−9; OR = 1.34). The association with GC differed by anatomic subsite. For tumors located in the cardia the association was stronger (P=4.19 × 10−15; OR= 1.57) and for those located in the noncardia stomach it was absent (P=0.44; OR=1.05). Our findings at 10q23 could provide insight into the high incidence rates of both cancers in China.
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