Rodent models of TDP-43: recent advances.
Rodent models of TDP-43: recent advances.
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DOI：
10.1016/j.brainres.2012.04.031
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发表时间：
2012-06-26
期刊：
影响因子：
2.9
通讯作者：
Wong PC
中科院分区：
文献类型：
--
作者：
Tsao W;Jeong YH;Lin S;Ling J;Price DL;Chiang PM;Wong PC
Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations in TDP-43 cause dysfunction and death of motor neurons, investigators have employed both gain- and loss-of-function studies in rodent model systems. Here, we will summarize major findings from the initial sets of TDP-43 transgenic and knockout rodent models, identify their limitations, and point to future directions toward clarification of disease mechanism(s) and testing of therapeutic strategies that ultimately may lead to novel therapy for this devastating disease.
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影响因子：
5.3
作者：
Fischer, LR;Culver, DG;Glass, JD
通讯作者：
Glass, JD
DOI：
10.1016/s1050-3862(96)00167-2
发表时间：
1996-12-01
期刊：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Borchelt, DR;Davis, J;Price, DL
通讯作者：
Price, DL
影响因子：
9.8
作者：
Chen, YZ;Bennett, CL;Chance, PF
通讯作者：
Chance, PF
DOI：
10.1073/pnas.1002176107
发表时间：
2010-09-14
影响因子：
11.1
作者：
Chiang, Po-Min;Ling, Jonathan;Wong, Philip C.
通讯作者：
Wong, Philip C.
影响因子：
16.2
作者：
Feng, GP;Mellor, RH;Sanes, JR
通讯作者：
Sanes, JR