Attributable Fraction of Influenza Virus Detection to Mild and Severe Respiratory Illnesses in HIV-Infected and HIV-Uninfected Patients, South Africa, 2012-2016.

Attributable Fraction of Influenza Virus Detection to Mild and Severe Respiratory Illnesses in HIV-Infected and HIV-Uninfected Patients, South Africa, 2012-2016.
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DOI:
10.3201/eid2307.161959
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发表时间:
2017-07
影响因子:
11.8
通讯作者:
Cohen C
Cohen C
中科院分区:
医学2区
文献类型:
--
作者:
Tempia S;Walaza S;Moyes J;Cohen AL;von Mollendorf C;McMorrow ML;Treurnicht FK;Venter M;Pretorius M;Hellferscee O;Wolter N;von Gottberg A;Nguweneza A;McAnerney JM;Dawood H;Variava E;Madhi SA;Cohen C

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尚未描述不同年龄组或不同 HIV 感染状态的患者的流感病毒检测对疾病的归因分数 (AF)。我们将流感样疾病 (ILI) 或严重急性或慢性呼吸道疾病(分别为 SARI 和 SCRI)患者中特定年龄组的流感病毒感染率与对照人群进行比较,并按 HIV 血清状态进行分层。流感病毒检测到疾病的总体 AF,ILI 为 92.6%,SARI 为 87.4%,SCRI 为 86.2%。在未感染 HIV 的患者中,所有综合征的 AF 在年龄 <1 岁和 >65 岁的人群中最高,在 25-44 岁的人群中最低;在艾滋病毒感染者中没有观察到这种趋势。总体而言,在 ILI、SARI 或 SCRI 患者中检测到流感病毒很可能归因于疾病。这一发现在儿童和老年人(无论艾滋病毒血清状态如何)以及艾滋病毒感染者(无论年龄)中尤其有可能出现。
The attributable fraction (AF) of influenza virus detection to illness has not been described for patients in different age groups or with different HIV infection statuses. We compared the age group–specific prevalence of influenza virus infection among patients with influenza-like illness (ILI) or severe acute or chronic respiratory illness (SARI and SCRI, respectively) with that among controls, stratified by HIV serostatus. The overall AF for influenza virus detection to illness was 92.6% for ILI, 87.4% for SARI, and 86.2% for SCRI. Among HIV-uninfected patients, the AF for all syndromes was highest among persons <1 and >65 years of age and lowest among persons 25–44 years of age; this trend was not observed among HIV-infected patients. Overall, influenza viruses when detected in patients with ILI, SARI, or SCRI are likely attributable to illness. This finding is particularly likely among children and the elderly irrespective of HIV serostatus and among HIV-infected persons irrespective of age.
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