The Brain after Cardiac Arrest.

The Brain after Cardiac Arrest.
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DOI:
10.1055/s-0036-1597833
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发表时间:
2017-03
影响因子:
2.7
通讯作者:
Callaway CW
Callaway CW
中科院分区:
医学3区
文献类型:
--
作者:
Elmer J;Callaway CW

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心脏骤停是常见且致命的。大多数患者在恢复自然循环后在医院接受治疗,仍然会死于缺氧脑损伤的后遗症。在这篇综述中,作者概述了睡眠后脑损伤的机制和后果。特别关注继发性脑损伤的潜在可改变机制,包括癫痫发作、高热、脑缺氧和脑灌注不足、氧化损伤和脑水肿的发展。最后,作者讨论了心脏骤停幸存者的结果,重点关注了常见的损伤模式,以及用于测量患者结果及其局限性的量表。
Cardiac arrest is common and deadly. Most patients who are treated in the hospital after achieving return of spontaneous circulation still go on to die from the sequelae of anoxic brain injury. In this review, the authors provide an overview of the mechanisms and consequences of postarrest brain injury. Special attention is paid to potentially modifiable mechanisms of secondary brain injury including seizures, hyperpyrexia, cerebral hypoxia and hypoperfusion, oxidative injury, and the development of cerebral edema. Finally, the authors discuss the outcomes of cardiac arrest survivors with a focus on commonly observed patterns of injury as well as the scales used to measure patient outcome and their limitations.
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