Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.
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DOI:
10.1016/j.jaci.2014.01.018
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发表时间:
2014-06
影响因子:
14.2
通讯作者:
Gergen, Peter J.
Gergen, Peter J.
中科院分区:
医学1区
文献类型:
--
作者:
Bousquet, Jean;Gern, James E.;Martinez, Fernando D.;Anto, Josep M.;Johnson, Christine C.;Holt, Patrick G.;Lemanske, Robert F., Jr.;Le Souef, Peter N.;Tepper, Robert S.;von Mutius, Erika R. M.;Arshad, S. Hasan;Bacharier, Leonard B.;Becker, Allan;Belanger, Kathleen;Bergstrom, Anna;Bernstein, David I.;Cabana, Michael D.;Carroll, Kecia N.;Castro, Mario;Cooper, Philip J.;Gillman, Matthew W.;Gold, Diane R.;Henderson, John;Heinrich, Joachim;Hong, Soo-Jong;Jackson, Daniel J.;Keil, Thomas;Kozyrskyj, Anita L.;Carlsen, Karin C. Lodrup;Miller, Rachel L.;Momas, Isabelle;Morgan, Wayne J.;Noel, Patricia;Ownby, Dennis R.;Pinart, Mariona;Ryan, Patrick H.;Schwaninger, Julie M.;Sears, Malcolm R.;Simpson, Angela;Smit, Henriette A.;Stern, Debra A.;Subbarao, Padmaja;Valenta, Rudolf;Wang, Xiaobin;Weiss, Scott T.;Wood, Robert;Wright, Anne L.;Wright, Rosalind J.;Togias, Alkis;Gergen, Peter J.

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以人口为基础的哮喘和过敏出生队列越来越多地为这些疾病的发展和自然历史提供了新的见解。在过去的30年里,已经启动了130多个关注哮喘和过敏的出生队列。NIAID(国家过敏和传染病研究所)、NHLBI(国家心肺和血液研究所)、MeDALL(过敏发展机制,欧盟委员会框架计划7)联合研讨会于2012年9月11-12日在美国马里兰州贝塞斯达举行,目的有3个:(1)记录哮喘/过敏出生队列提供的知识,(2)找出知识差距和不一致之处,(3)制定向前推进的策略,包括潜在的新研究设计和协调现有哮喘出生队列数据。会议围绕5个不同工作组的发言进行组织:(1)临床表型,(2)危险因素,(3)哮喘和过敏的免疫发展,(4)肺部发育和(5)现有出生队列的协调。这份手稿介绍了工作组的报告,并提供了网络链接(AsthmaBirthCohorts.niaid.nih.gov或www.medall-fp7.eu),读者可以在那里找到表格,描述本报告所包括的出生队列的特征、不同年龄收集的数据类型以及参与的出生队列提供的选定参考书目。
Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. Over 130 birth cohorts focusing on asthma and allergy have been initiated in the last 30 years. A NIAID (National Institute of Allergy and Infectious Diseases), NHLBI (National Heart Lung and Blood Institute), MeDALL (Mechanisms of the Development of Allergy, Framework Programme 7 of the European Commission) joint workshop was held in Bethesda, MD, USA September 11–12, 2012 with 3 objectives (1) documenting the knowledge that asthma/allergy birth cohorts have provided, (2) identifying the knowledge gaps and inconsistencies and (3) developing strategies for moving forward, including potential new study designs and the harmonization of existing asthma birth cohort data. The meeting was organized around the presentations of 5 distinct workgroups: (1) clinical phenotypes, (2) risk factors, (3) immune development of asthma and allergy, (4) pulmonary development and (5) harmonization of existing birth cohorts. This manuscript presents the workgroup reports and provides web links (AsthmaBirthCohorts.niaid.nih.gov or www.medall-fp7.eu) where the reader will find tables describing the characteristics of the birth cohorts included in this report, type of data collected at differing ages, and a selected bibliography provided by the participating birth cohorts.
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