Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts.
Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts.
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DOI：
10.1371/journal.pone.0043214
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
GALEN WP 1.5 ‘Birth Cohorts’ working group
中科院分区：
文献类型：
--
作者：
Lødrup Carlsen KC;Roll S;Carlsen KH;Mowinckel P;Wijga AH;Brunekreef B;Torrent M;Roberts G;Arshad SH;Kull I;Krämer U;von Berg A;Eller E;Høst A;Kuehni C;Spycher B;Sunyer J;Chen CM;Reich A;Asarnoj A;Puig C;Herbarth O;Mahachie John JM;Van Steen K;Willich SN;Wahn U;Lau S;Keil T;GALEN WP 1.5 ‘Birth Cohorts’ working group
研究儿童早期饲养宠物与6-10岁儿童哮喘和过敏之间的关系。对11个前瞻性欧洲出生队列的个体参与者数据进行了汇总分析，这些队列在20世纪90年代共招募了22，000多名儿童。在生命的前2年内仅拥有猫、狗、鸟类、啮齿动物或猫/狗的所有权。6-10岁期间的当前哮喘（主要结局）、过敏性哮喘、过敏性鼻炎和过敏性致敏。分三步走：（i）跨队列结果和暴露变量的共同定义;（ii）计算每个队列的调整后效应估计值;（iii）使用随机效应荟萃分析模型汇总效应估计值。我们发现幼年饲养毛茸茸的宠物和学龄期哮喘之间没有联系。例如，养猫与“不养宠物”（10项研究，11489名参与者）相比，哮喘的比值比为1.00（95%置信区间为0.78至1.28）（I2 = 9%; p = 0.36）。 养狗与“不养宠物”（9项研究，11433名参与者）相比，哮喘的比值比为0.77（0.58 - 1.03）（I2 = 0%，p = 0.89）。 同时养猫和狗与“不养宠物”相比，优势比为1.04（0.59至1.84）（I2 = 33%，p = 0.18）。 同样，对于过敏性哮喘和过敏性鼻炎，我们没有发现与生命早期任何类型的宠物所有权有关。然而，我们发现一些证据表明，在生命的前2年拥有毛茸茸的宠物与对空气过敏原敏感的可能性降低之间存在关联。在6-10岁的儿童中，早期养宠物似乎不会增加或减少哮喘或过敏性鼻炎症状的风险。不应建议卫生保健从业人员避免或专门购买宠物作为儿童哮喘或过敏性鼻炎的一级预防。
To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6–10 years. Pooled analysis of individual participant data of 11 prospective European birth cohorts that recruited a total of over 22,000 children in the 1990s. Ownership of only cats, dogs, birds, rodents, or cats/dogs combined during the first 2 years of life. Current asthma (primary outcome), allergic asthma, allergic rhinitis and allergic sensitization during 6–10 years of age. Three-step approach: (i) Common definition of outcome and exposure variables across cohorts; (ii) calculation of adjusted effect estimates for each cohort; (iii) pooling of effect estimates by using random effects meta-analysis models. We found no association between furry and feathered pet keeping early in life and asthma in school age. For example, the odds ratio for asthma comparing cat ownership with “no pets” (10 studies, 11489 participants) was 1.00 (95% confidence interval 0.78 to 1.28) (I2 = 9%; p = 0.36). The odds ratio for asthma comparing dog ownership with “no pets” (9 studies, 11433 participants) was 0.77 (0.58 to 1.03) (I2 = 0%, p = 0.89). Owning both cat(s) and dog(s) compared to “no pets” resulted in an odds ratio of 1.04 (0.59 to 1.84) (I2 = 33%, p = 0.18). Similarly, for allergic asthma and for allergic rhinitis we did not find associations regarding any type of pet ownership early in life. However, we found some evidence for an association between ownership of furry pets during the first 2 years of life and reduced likelihood of becoming sensitized to aero-allergens. Pet ownership in early life did not appear to either increase or reduce the risk of asthma or allergic rhinitis symptoms in children aged 6–10. Advice from health care practitioners to avoid or to specifically acquire pets for primary prevention of asthma or allergic rhinitis in children should not be given.
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影响因子：
168.9
作者：
Celedón, JC;Litonjua, AA;Gold, DR
通讯作者：
Gold, DR
影响因子：
4.4
作者：
Bråbäck, L;Kjellman, NIM;Björkstén, B
通讯作者：
Björkstén, B
影响因子：
7.7
作者：
BRUNEKREEF, B;GROOT, B;HOEK, G
通讯作者：
HOEK, G
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
6.1
作者：
Anyo, G;Brunekreef, B;van Vliet, P
通讯作者：
van Vliet, P