Near-infrared fluorescent nanocapsules with reversible response to thermal/pH modulation for optical imaging.
Near-infrared fluorescent nanocapsules with reversible response to thermal/pH modulation for optical imaging.
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DOI：
10.1021/bm201350d
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发表时间：
2011-12-12
影响因子：
6.2
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Chen Y;Li X
制备了聚合物近红外（NIR）荧光纳米胶囊，其荧光对局部热/pH调制具有可逆响应。我们的策略是使用由温度敏感的Pluronic F-127制成的聚合物胶束在核心内封装两亲性近红外荧光染料吲哚菁绿（ICG），然后通过ph敏感的聚乙烯亚胺（PEI）交联胶束电晕。利用温度升高/降低引起的胶束大小膨胀/收缩特性作为控制纳米胶囊荧光产率的开关。结果表明，随着温度的升高，荧光产率显著增加。PEI交联使得荧光产率对局部pH变化也很敏感，并且增强了纳米胶囊的细胞内递送。初步结果表明，该近红外荧光探针可作为对局部环境敏感的造影剂用于平移光学成像/传感。
Polymeric near-infrared (NIR) fluorescent nanocapsules were developed, of which the fluorescence exhibited reversible response to local thermal/pH modulation. Our strategy was to use polymeric micelles made of temperature-sensitive Pluronic F-127 to encapsulate an amphiphilic NIR fluorescent dye—indocyanine green (ICG)—within the core and then cross-link the micelle corona by pH-sensitive poly(ethylenimine) (PEI). The size swelling/shrinking property of the micelles induced by temperature decrease/increase was used as a switch to control the fluorescence yield of the nanocapsules. It was found that the fluorescence yield significantly increased with the increase in temperature. The PEI cross-link made the fluorescence yield also sensitive to local pH change and enhanced intracellular delivery of the nanocapsules as well. Preliminary results suggest the NIR fluorescent probes could be potentially used as a contrast agent sensitive to local environment for translational optical imaging/sensing.
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