Plasma gas discharge deposited fluorocarbon polymers exhibit reduced elutability of adsorbed albumin and fibrinogen.

Plasma gas discharge deposited fluorocarbon polymers exhibit reduced elutability of adsorbed albumin and fibrinogen.
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等离子气体放电沉积的碳氟聚合物表现出吸附的白蛋白和纤维蛋白原的洗脱性降低。

DOI:
10.1163/156856289x00154
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发表时间:
1990
期刊:
Journal of biomaterials science. Polymer edition
影响因子:
--
通讯作者:
Hoffman,AS
Hoffman,AS
中科院分区:
--
文献类型:
--
作者:
Bohnert,JL;Fowler,BC;Horbett,TA;Hoffman,AS

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纤维蛋白原和白蛋白的吸附和随后的洗涤剂洗脱性进行了测量,在各种处理和未处理的聚合物膜,以确定这些蛋白质的相对吸附是否是负责增强的抗血栓性的涤纶血管移植物处理的射频辉光放电(RFGD)装置。通过RFGD处理聚对苯二甲酸乙二酯(PET)膜,用正丁烷或全氟丙烷制备了不同CF、CF 2 '和CF基团的相对比例以及氟与碳的比例的氟碳涂层表面。纤维蛋白原和白蛋白对这些氟碳涂层表面的吸附与蛋白质对聚四氟乙烯(PTFE)和PET的吸附相当。然而,纤维蛋白原和白蛋白从RFGD氟碳表面与十二烷基硫酸钠的洗脱率远低于从PTFE或PET。PET的其他RFGD处理,例如乙烯沉积或氩气蚀刻,并没有像RFGD氟碳化合物处理那样显着降低白蛋白可洗脱性的程度。白蛋白与RFGD碳氟表面的强结合可在临床上用于增强预吸附到血液接触表面的白蛋白的保留,以使其具有抗血栓性。
The adsorption and subsequent detergent elutability of fibrinogen and albumin were measured on various treated and untreated polymer films in order to determine whether the relative adsorption of these proteins was responsible for the enhanced thromboresistance of Dacron vascular grafts treated with tetrafluoroethylene in a radio frequency glow discharge (RFGD) apparatus. Fluorocarbon-coated surfaces varying in the relative proportions of CF, CF2' and CF groups and in the ratio of fluorine to carbon were prepared by RFGD treatment of poly(ethylene terephthalate) (PET) films with tetrafluoroethylene or perfluoropropane. The adsorption of fibrinogen and albumin to these fluorocarbon-coated surfaces was comparable to the adsorption of the proteins to polytetrafluoroethylene (PTFE) and PET. However, the elutability of fibrinogen and albumin from the RFGD fluorocarbon surfaces with sodium dodecyl sulfate was much lower than that from PTFE or PET. Other RFGD treatments of PET, such as ethylene deposition or argon etching, did not reduce the extent of albumin elutability as dramatically as did the RFGD fluorocarbon treatments. The strong albumin binding to RFGD fluorocarbon surfaces may be exploited clinically to enhance the retention of albumin preadsorbed to blood-contacting surfaces fo render them thromboresistant.
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DOI: --
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