Glycomics and disease markers.

Glycomics and disease markers.
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DOI:
10.1016/j.cbpa.2009.08.015
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发表时间:
2009-12
影响因子:
7.8
通讯作者:
Lebrilla, Carlito B.
Lebrilla, Carlito B.
中科院分区:
生物学2区
文献类型:
--
作者:
An, Hyun Joo;Kronewitter, Scott R.;de Leoz, Maria Lorna A.;Lebrilla, Carlito B.

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糖组学是对生物系统中表达的所有聚糖的综合研究。聚糖的生物合成依赖于许多涉及糖基转移酶的高度竞争性过程。因此,糖基化对生物化学环境高度敏感,并与包括癌症在内的许多疾病有关。最近,由于聚糖作为疾病标志物的潜力,对糖组谱分析的兴趣增加。在这方面,质谱法正在成为一种强大的技术,用于分析糖组。基于质谱的人血清的全球聚糖谱分析已经导致了几种类型的癌症和疾病的几种潜在的有希望的标志物。
Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferase. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased due to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.
DOI: 10.1158/1078-0432.ccr-07-5261
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影响因子: --
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